QF0159 Marketing Release Record

CD3
Clone PS1
50 Tests ORG-8982
Antigen Background
The CD3 antigen is a marker of T cell differentiation, expressed in normal and
neoplastic T cells. The CD3 antigen is first detected in early thymocytes and
its appearance probably represents one of the earliest indicators of
commitment to the T cell lineage.
Product Specific Information
T cell phenotype in lymphoproliferative disorders may be indicated using
Origin CD3 (Clone PS1) as part of a panel of antibodies.
Refer to page 33 for further information about Clone PS1.
Origin CD3 (Clone PS1) on tonsil. Paraffin section.
CD4
Clone 1F6
50 Tests ORG-8756
Antigen Background
The CD4 antigen is expressed on a T cell subset (helper/inducer) representing
45 percent of peripheral blood lymphocytes and at a lower level on
monocytes. Most cases of cutaneous T cell lymphoma, including mycosis
fungoides, express the CD4 antigen. HTLV-1 associated adult T cell leukemia/
lymphoma is also generally CD4 positive.
Origin CD4 (Clone 1F6) on tonsil.
IVD
IVD
CD5
Clone 4C7
50 Tests ORG-8919
Antigen Background
IVD
CD5 is a protein of 67 kD, expressed on 95 percent of thymocytes and 72
percent of peripheral blood lymphocytes. In lymph nodes, the main reactivity
is observed on T cells. CD5 antigen is expressed by many T cell lymphomas,
activated T cells and on a subset of B cells. CD5 antigen expression is
reported in T cell acute lymphocytic leukemias (T-ALL), some B cell chronic
lymphocytic leukemias (B-CLL) as well as B and T cell lymphomas. CD5
antigen is not expressed in follicular cell lymphomas.
Product Specific Information
Origin CD5 (Clone 4C7) can be used in the differential diagnosis of lymphomas,
including mantle cell lymphomas.
Origin CD5 (Clone 4C7) on spleen. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Origin