QF0159 Marketing Release Record

Ki67
Clone MM1
50 Tests ORG-8772
Antigen Background
Ki67 is a nuclear cell cycle associated protein, which is expressed in all
active parts of the cell cycle (G1, S, G2 and mitosis) but not in resting cells
(G0). In contrast to many other cell cycle associated proteins the Ki67 antigen
is consistently absent in quiescent cells and is not detectable during DNA
repair processes. Thus, the presence of Ki67 is strictly associated with the
cell cycle and confined to the nucleus.
Product Specific Information
Origin Ki67 (Clone MM1) can be utilized in the assessment of cell proliferation
in normal and neoplastic tissues.
Refer to page 76 for further information about Clone MM1.
Origin Ki67 (Clone MM1) on breast carcinoma. Paraffin section.
Melan A
Clone A103
50 Tests ORG-8953
Antigen Background
IVD IVD
Melan A, a product of the MART-1 gene, is a melanocyte differentiation
marker recognized by autologous cytotoxic T lymphocytes. Other melanomaassociated
markers recognized by autologous cytotoxic T cells are reported
to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1.
The analysis of these different molecules and their expression in individual
melanomas may be of help in the study of their particular roles in
tumorigenesis.
Product Specific Information
Origin Melan A (Clone A103) is recommended for the assessment of Melan A
in melanocytic lesions.
Refer to page 80 for further information about Clone a103.
Origin Melan A (Clone A103) on malignant melanoma. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
/ 139
Origin