QF0159 Marketing Release Record

Primary Antibodies
Novocastra CD7
Clone LP15 Reference Range
1 mL, 0.1 mL liquid NCL-L-CD7-580 P (HIER)
7 mL BOND ready-to-use PA0266 P (HIER)
Antigen Background
The CD7 molecule is a membrane-bound glycoprotein of 40 kD and is the
earliest T cell specific antigen to be expressed in lymphocytes. CD7 antigen
is also the only early marker to persist throughout differentiation. The function
and role of the CD7 molecule has not yet been fully identified, although the
activation of T cells with gamma/delta receptors has been proposed based on
mAb-induced activation. CD7 antigen is reported to be found on the majority
of peripheral blood T cells, most natural killer cells and thymocytes.
Product Specific Information
Clone LP15 was developed to provide superior staining to clone CD7-272 on
paraffin sections.
Human thymus: immunohistochemical staining for CD7 antigen using NCL-L-CD7-580.
Note intense staining of cortical thymocytes. Paraffin section.
Novocastra CD8
Clone 1A5 Reference Range
1 mL, 0.1 mL lyophilized NCL-CD8-295 F P (HIER) W
1 mL liquid NCL-L-CD8-295 F P (HIER) W IVD
7 mL ready-to-use RTU-CD8-295 F P (HIER) IVD
Clone 4B11
1 mL, 0.1 mL lyophilized NCL-CD8-4B11 F P (HIER) W
7 mL BOND ready-to-use PA0183 P (HIER) IVD
Antigen Background
The CD8 molecule is composed of two chains and has a molecular weight of
32 kD. It is found on a T cell subset of normal cytotoxic/suppressor cells which
make up approximately 20 to 35 percent of human peripheral blood
lymphocytes. The CD8 antigen is reported to be detected on natural killer
cells, 80 percent of thymocytes, on a subpopulation of 30 percent of
peripheral blood null cells and 15 to 30 percent of bone marrow cells.
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IVD
IVD
IVD
IVD
Large T cell immunoblastic lymphoma: immunohistochemical staining for CD8 antigen using
NCL-CD8-295. Note intense membrane staining of T lymphocytes. Paraffin section.
Novocastra CD9 (Motility-Related
Protein-1)
Clone 72F6
1 mL lyophilized NCL-CD9 F P (HIER)
RUO*
CD9 antigen is a 24 to 27 kD glycoprotein expressed on the surface of
developing B lymphocytes, platelets, monocytes, eosinophils, basophils,
stimulated T lymphocytes and by neurons and glial cells in the peripheral
nervous system. It belongs to a family of membrane proteins termed
tetraspanins which transverse the membrane four times. In pre-B cells and
platelets, CD9 antigen regulates cell activation and aggregation possibly
through an association with the integrin CD41/CD61 (GPIIb/GPIIIa). It also
regulates cell motility in a variety of cell lines and appears to be an
important regulator of Schwann cell behavior in the peripheral nervous
system. In melanoma and breast cancer, CD9 antigen expression has been
reported to occur predominantly on primary, non-metastatic tumors.
Human fibroadenoma: immunohistochemical staining for CD9 antigen using NCL-CD9.
Note intense membrane staining of tumor cells. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.