QF0159 Marketing Release Record

Novocastra CD163
Clone 10D6
1 mL lyophilized NCL-CD163 P (HIER)
Antigen Background
The CD163 molecule is a type I membrane protein also known as M130
antigen, Ber-Mac3, Ki-M8 or SM4. CD163 protein is restricted in its
expression to the monocytic/macrophage lineage. It is reported to be present
on all circulating monocytes and most tissue macrophages except those
found in the mantle zone and germinal centers of lymphoid follicles,
interdigitating reticulum cells and Langerhans cells. In addition, multinucleated
cells within inflammatory lesions are reported not to express
CD163 protein. The protein is upregulated by glucocorticoids and
downregulated by the immunosuppressant cyclosporin A and by phorbol
esters, while lipopolysaccharide, an inflammatory mediator, has no influence
on expression. It has been proposed that a specific release mechanism of
soluble CD163 antigen by human monocytes may play an important role in
modulating inflammatory processes.
Human placenta: immunohistochemical staining for CD163 antigen using NCL-CD163. Note
intense membrane and cytoplasmic staining of villous macrophages. Paraffin section.
Novocastra CD205 (DEC-205)
Clone 11A10
1 mL liquid NCL-L-DEC205 P (HIER)
RUO*
CD205 is a 205 kD integral membrane glycoprotein homologous to the
macrophage mannose receptor and related receptors. It is a novel
multilectin, endocytic receptor that can be used by dendritic cells and
thymic epithelial cells to direct captured antigens from extracellular spaces
to a specialized antigen processing compartment.
Human thymus: immunohistochemical staining for DEC-205 using NCL-L-DEC205.
Note cytoplasmic and membrane staining of epithelial cells. Paraffin section.
IVD
Novocastra CD243 (P-glycoprotein)
Clone 5B12
1 mL lyophilized NCL-PGLYm F P (HIER)
See also P-glycoprotein (CD243) on page 95.
Novocastra CD246 (Anaplastic
Lymphoma Kinase) (ALK) (p80)
Clone 5A4
1 mL, 0.1 mL lyophilized NCL-ALK P (HIER)
7 mL BOND ready-to-use PA0306 P (HIER)
See also ALK (Anaplastic Lymphoma Kinase) (CD246) (p80) on page 20.
Novocastra CDX2
Clone AMT28 Reference Range
1 mL lyophilized NCL-CDX2 P (HIER) IVD
7 mL BOND ready-to-use PA0535 P (HIER)
Antigen Background
CDX2 is a caudal-type homeobox, intestine-specific transcription factor that
is expressed early in intestinal development and may be involved in the
regulation of proliferation and differentiation of intestinal epithelial cells.
CDX2, as well as CDX1, is of particular interest as the intestine is the only
organ that contains detectable levels of either gene product. This pattern of
restricted expression is unusual for homeobox genes. Phosphorylation of the
CDX2 activation domain can modulate its function and different spatial
expression patterns in the intestinal epithelium. CDX2 is primarily expressed
on the surface of the villus and in the crypts. In contrast to CDX1, intense
CDX2 expression is reported to occur in all but the distal portions of the
developing intestine. The loss of CDX2 has been reported to contribute
towards the progression of some sporadic colorectal cancers. It has been
reported that CDX2 may also be associated with carcinogenesis of the
stomach as expression of CDX2 mRNA progressively decreases with the
transition from well differentiated to poorly differentiated gastric cancer cell
lines.
Human small intestine: immunohistochemical staining for CDX2 homeobox protein using
NCL-CDX2. Note nuclear and cytoplasmic staining of epithelial cells. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
IVD
IVD
IVD
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Primary Antibodies