QF0159 Marketing Release Record

Novocastra Mast Cell Chymase
Clone CC1
1 mL lyophilized NCL-MCC P (HIER)
Novocastra Maspin
Clone EAW24
1 mL, 0.1 mL lyophilized NCL-MASPIN P (HIER)
Maspin, or mammary-specific serpin, is a tumor suppressor protein of 42 kD
that belongs to the serine proteinase inhibitor (serpin) family. It is reported to be
expressed in normal breast and prostatic epithelial cells but is downregulated
in carcinomas derived from these cell types. The expression of maspin is
controlled at the transcriptional level by a combination of elements including
Ets, AP-1 and p53. The tumor suppressor activity of maspin may depend on its
ability to inhibit angiogenesis. In breast myoepithelial cells, maspin is
predominantly a soluble cytoplasmic protein which associates with secretory
vesicles and is present at the cell surface. The loss of maspin in breast tumors
is reported to be a progressive process and expression decreases with
increasing malignancy of primary tumors and is absent from lymph node and
distant metastases. In rats, maspin mRNA has been detected in mammary
gland, vagina, bladder, thymus, small intestine, ventral prostate, seminal
vesicles and thyroid, but is absent from heart, lung, liver, brain and kidney.
Human prostate: immunohistochemical staining for maspin using NCL-MASPIN. Note
cytoplasmic and nuclear staining of normal glandular basal cells. Paraffin section.
Novocastra Mast Cell Tryptase
Clone 10D11
1 mL lyophilized NCL-MCTRYP-428 P
7 mL BOND ready-to-use PA0019 P
RUO*
Mast cells contain a number of preformed chemical mediators such as
histamine, chymase, carboxypeptidase and proteolytic tryptase. A
substantial quantity of tryptase is reported to be found in mast cells of skin
and lung and suggests this enzyme plays a major role in mast cell mediated
events. In vitro studies indicate tryptase can cleave C3 to form C3a
anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin
and activate latent collagenase. Models of allergenic disease in the skin,
nose and lung have each indicated elevated tryptase levels. Human mast
cell tryptase has been reported to be implicated as a mediator of
inflammation. Mast cell degranulation in the gut causes mucus secretion,
mucosal edema, increased gut permeability and may be responsible for
some of the symptoms and signs of inflammatory bowel disease.
IVD
IVD
IVD
Human appendix: immunohistochemical staining for mast cell tryptase using NCL-MCTRYP-
428. Note cytoplasmic staining of mast cells. Paraffin section.
Novocastra Matrix Metalloproteinase
Antibodies
Clone 17B11
1 mL, 0.1 mL lyophilized Matrix Metalloproteinase 2
NCL-MMP2-507 P (HIER) RUO*
Clone 15W2
1 mL, 0.1 mL lyophilized Matrix Metalloproteinase 9
NCL-MMP9-439 FP RUO*
Clone 5E4
1 mL lyophilized Matrix Metalloproteinase 10
NCL-MMP10 P (HIER) RUO*
Novocastra MB2 (B Cell Marker)
Clone MB2
1 mL lyophilized NCL-MB2 FP
See also B Cell Marker (MB2) on page 23.
Novocastra MCAM (CD146)
Clone N1238
1 mL lyophilized NCL-CD146 P (HIER) W
See also CD146 (MCAM) on page 46.
RUO*
IVD
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies