QF0159 Marketing Release Record

Primary Antibodies
Novocastra Luteinizing Hormone
Clone C93 New!
7 mL BOND ready-to-use PA0655 P
Antigen Background
Luteinising hormone (LH) is a trophic hormone which modulates the secretory
activity of other endocrine glands. It is produced by the anterior hypophysis
of the pituitary gland. This glycoprotein hormone, like human follicle
stimulating hormone and thyroid stimulating hormone, is composed of a
common alpha-subunit and a specific beta-subunit which characterizes each
of these hormones.
Pituitary: immunohistochemical staining with BOND ready-to-use Luteinizing Hormone (C93)
using BOND Polymer Refine Detection.
Novocastra Lysozyme (Muramidase)
Polyclonal
1 mL lyophilized NCL-MURAM ASR
7 mL BOND ready-to-use PA0391 P (Enzyme) IVD
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Novocastra Mac-1 (CD11b)
Clone 44
1 mL lyophilized NCL-CD11b F
See also CD11b (Mac-1) on page 35.
Novocastra Macrophage Marker (LN-5)
Clone LN-5
1 mL lyophilized NCL-LN5 F P (Enzyme)
Different types of lymphomas of true histiocytic origin can be characterized
with various panels of antibodies. Expression of different phenotypes in socalled
true histiocytic lymphoma and malignant histiocytosis has been
observed but all express a group of markers that includes LN5. Hsu SM et al.
American Journal of Pathology. 138(6):1389-404 (1991).
Product Specific Information
Clone LN-5 stains the cytoplasm of macrophages and histiocytes in
hematopoietic organs. The heat induced epitope retrieval (HIER) technique
may enhance staining in some cases.
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RUO*
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IVD
RUO*
Human small intestine: immunohistochemical staining for a marker of the histiocyte/
macrophage series using NCL-LN5. Note intense cytoplasmic staining of macrophages.
Paraffin section.
Novocastra Macrophage Marker
(MAC387)
Clone MAC387
1 mL lyophilized NCL-MAC387 F P (Enzyme)
7 mL BOND ready-to-use PA0752 P (HIER)
L1, a member of the S-100 family of proteins, is reported to be found on
neutrophils, monocytes, certain reactive macrophages and squamous
mucosal epithelia.
Product Specific Information
Clone MAC387 is reported to be specific for the leucocyte antigen L1.
Novocastra MAGE-1
Clone 6C1
1 mL lyophilized NCL-MAGE-1 P (HIER)
RUO*
The human MAGE gene products are recognised by major
histocompatability complex-restricted cytotoxic T lymphocytes. MAGE-1,
also known as tumor rejection antigen, is a target for immunotherapy in
patients with hepatocellular carcinoma (HCC). MAGE-1 is reported to be
expressed in about 60 per cent of HCC cases. Other studies utilising reverse
transcriptase-PCR and southern blot hybridisation techniques have reported
MAGE genes to be expressed in malignant tumors and pre-cancerous
lesions but not in benign tumors.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
IVD
RUO*