QF0159 Marketing Release Record

Human insulinoma: immunohistochemical staining for chromogranin A using NCL-CHROM-430.
Note intense cytoplasmic staining of neoplastic islet cells. Paraffin section.
Novocastra c-jun Oncoprotein
Clone DK4
1 mL lyophilized NCL-cJUN F P (Enzyme)
c-jun is the normal cellular homolog of the transforming gene of avian
sarcoma virus 17 and is a member of the early-response gene family. The cjun
oncogene encodes a nuclear protein, p39, which is a major component
of the transcription factor AP1 and interacts with the c-fos oncogene
product forming a transacting heterodimer. c-jun oncoprotein plays an
important role in the regulation of gene expression and signal transduction
processes. Alterations in c-jun expression may affect the transcriptional
initiation of specific target genes and as a consequence may affect normal
cell growth and function.
Human breast carcinoma: immunohistochemical staining for c-jun oncoprotein using
NCL-cJUN. Note nuclear staining of tumor cells. Paraffin section.
Novocastra c-MET (Hepatocyte Growth
Factor Receptor)
Clone 8F11
1 mL lyophilized NCL-cMET F P (HIER)
The c-MET gene encodes a transmembrane tyrosine kinase identified as the
receptor for a polypeptide known as hepatocyte growth factor (HGF). HGF
has been shown to exert a pleiotropic activity on several cell types mainly of
epithelial origin. It is a powerful mitogen for hepatocytes and also stimulates
the growth of other cell types including kidney tubular cells, keratinocytes
and endothelial cells. Other cell types known to express c-MET include
hepatocytes, microglial cells in white matter and astrocytes.
IVD
RUO*
Novocastra c-myc Oncoprotein
Clone 9E11
1 mL lyophilized NCL-cMYC FP
The c-myc oncogene is the human cellular homolog of the avian v-myc gene
found in several leukemogenic retroviruses. c-myc is a nuclear phosphoprotein,
which has DNA-binding activity and is implicated in the control of
normal proliferation and differentiation. Expression of c-myc in
untransformed cells is growth factor dependent and essential for
progression through the cell cycle. c-myc is expressed during proliferation
in a wide variety of adult tissues and at all stages of embryonic
development.
Product Specific Information
Enzyme pretreatment may enhance staining in some cases.
Novocastra Collagen Type II
Polyclonal
1 mL lyophilized NCL-COLL-IIp P (Enzyme)
Collagen type II is the structural protein predominantly found throughout the
cartilage matrix and is also found in very small amounts in the eye. The
fibrils formed by this protein are usually thinner and more delicate than
collagen type I fibrils.
Product Specific Information
NCL-COLL-IIp reacts with type II collagen and does not cross-react with
collagen types I, III, IV, V, VI, other human serum proteins or non-collagenous
extracellular associated proteins.
Human chondrosarcoma: immunohistochemical staining for collagen type II using NCL-COLL-
IIp. Note diffuse staining of chondroid tissue. Paraffin section.
Novocastra Collagen Type IV
Clone PHM-12
1 mL lyophilized NCL-COLL-IV ASR
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
IVD
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Primary Antibodies