QF0159 Marketing Release Record

CD79a
Clone 11E3
50 Tests ORG-8975
Antigen Background
CD79a is a cytoplasmic domain, disulfide linked heterodimer protein. This
protein is noncovalently associated with the membrane bound
immunoglobulins on B cells. This complex of polypeptides and
immunoglobulin constitutes the B cell receptor. The two components of this
complex are designated CD79a and CD79b. The CD79a antigen is reported to
first appear at the pre-B cell stage where it is found as an intracellular
component. The CD79a antigen is reported in the majority of acute leukemias
of precursor B cell types, B cell lines, B cell lymphomas and in some
myelomas. It is not present in myeloid or T cell lines.
Product Specific Information
An antibody panel including Origin CD79a (Clone 11E3) may be used in the
characterization of B cell disorders.
Refer to page 43 for further information about Clone 11E3.
Origin CD79a (Clone 11E3) on tonsil. Paraffin section.
Cytokeratin
Clone 34�E12
50 Tests ORG-8735
Antigen Background
IVD IVD
The expression of different cytokeratins in epithelial-derived tumors and the
general tendency towards maintenance of cytokeratin polypeptide patterns
during malignant growth and metastasis serves as a basis for approaching
the characterization of tumors, using cytokeratins as differentiation markers.
Product Specific Information
Origin Cytokeratin (Clone 34�E12) is recommended for the characterization of
squamous and ductal carcinomas arising from complex epithelia and is of
value in the differentiation of benign and malignant small-acinar lesions of the
prostate gland.
Refer to page 84 for further information about Clone 34�E12.
Origin Cytokeratin (Clone 34�E12) on squamous cell carcinoma. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Origin