QF0159 Marketing Release Record

Origin
Melanosome
Clone HMB45
50 Tests ORG-8854
Antigen Background
The melanosome antigen has been identified in retinal pigment epithelium
(RPE) but is reported to be reactive only with transient prenatal and infantile
RPE. Tumor cells of epithelial lymphoid, glial and mesenchymal origin are
reported to be negative.
Product Specific Information
Origin Melanosome (Clone HMB45) is recommended for use as part of a panel
of antibodies for the diagnosis of melanoma.
Refer to page 65 for further information about Clone HMB45.
Origin Melanosome (Clone HMB45) on malignant melanoma. Paraffin section.
Progesterone Receptor
Clone 16
50 Tests ORG-8721
Antigen Background
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94
kD) and PRB (114 kD), which function as ligand-activated transcription
factors. The PRA form is a truncated version of the PRB form, lacking the first
164 N-terminal amino acids. In humans, PRA activity acts as a transdominant
repressor of the transcriptional of PRB, glucocorticoid receptor, ER,
androgen receptor and mineralocorticoid receptor.
Product Specific Information
Origin Progesterone Receptor (Clone 16) binds specifically to the PRA antigen
in the nuclei of normal and neoplastic tissues, as such it is recommended for
determining the progesterone receptor alpha status of breast cancer tissue.
Refer to page 152 for further information about Clone 16.
Origin Progesterone Receptor (Clone 16) on breast carcinoma. Paraffin section.
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IVD
IVD
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Synaptophysin
Clone 27G12
50 Tests ORG-8848
Antigen Background
IVD
The Synaptophysin antigen is an integral membrane glycoprotein present in
many human normal and neoplastic neuroendocrine cells. It is reported to
occur in presynaptic vesicles of the neurons in the brain, spinal cord and
retina and in similar vesicles in the adrenal medulla and as well as
neuromuscular junctions. The synaptophysin antigen may be involved in
synaptic vesicle formation and exocytosis.
Product Specific Information
Synaptophysin (Clone 27G12) is recommended for the identification of tumors
of neuroendocrine origin and differentiation.
Refer to page 103 for further information about clone 27G12.
Origin Synaptophysin (Clone 27G12) on carcinoid tumor. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.