QF0159 Marketing Release Record

Primary Antibodies
Novocastra Cytokeratin, Multi
(4/5/6/8/10/13/18)
Clone C-11
1 mL lyophilized NCL-C11 F P (HIER)
See also Multi-Cytokeratin (4/5/6/8/10/13/18) on page 84.
Novocastra Cytokeratin, Multi (5/6/8/18)
Clone 5D3, Clone LP34 cocktail
1 mL lyophilized NCL-CK5/6/8/18 F P (Enzyme)
1 mL liquid NCL-L-CK5/6/8/18 F P (Enzyme) RUO*
7 mL ready-to-use RTU-CK5/6/8/18 F P (Enzyme)
See also Multi-Cytokeratin (5/6/8/18) on page 84.
Novocastra Cytomegalovirus Antibodies
Clone 2, Clone 6 cocktail
1 mL lyophilized Cytomegalovirus (pp65 antigen)
NCL-CMVpp65 ASR
Clone QB1/42
1 mL lyophilized Cytomegalovirus (early antigen)
NCL-CMV-EA F P (HIER) RUO*
Clone QB1/06
1 mL lyophilized Cytomegalovirus (late antigen)
NCL-CMV-LA F P (HIER) RUO*
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Novocastra Daxx
Clone 36H11
1 mL lyophilized NCL-DAXX P (HIER)
Daxx binds the death domain of Fas and links this receptor to an apoptosis
pathway involving the activation of Jun N-terminal kinase (JNK). The human
homolog of Daxx enhances Fas-mediated apoptosis probably by modulating
the transcription of genes involved in Fas-induced caspase activation and
apoptosis. The Fas-binding domain of Daxx is a dominant negative inhibitor
of both Fas-induced apoptosis and JNK inactivation, while the FADD death
domain partially inhibits death but not JNK activation. The Daxx apoptotic
pathway is sensitive to both bcl-2 and dominant negative JNK pathway
components and acts cooperatively with the FADD pathway. Therefore,
Daxx and FADD define two distinct pathways downstream of Fas. Daxx
mRNA is widely expressed in human tissues such as heart, brain, lung, liver,
skeletal muscle, kidney, pancreas and placenta. The human Daxx gene has
been mapped to 6p21.3 in the major histocompatibility complex (MHC)
region. Its location may help in understanding the genetic basis of autoimmune
diseases. In cells, the protein is found in the nucleus and to a lesser
extent in the cytoplasm.
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IVD
RUO*
RUO*
RUO*
Human breast carcinoma: immunohistochemical staining for Daxx using NCL-DAXX. Note
cytoplasmic and occasional nuclear staining. Paraffin section.
Novocastra DEC-205 (CD205)
Clone 11A10
1 mL liquid NCL-L-DEC205 P (HIER)
See also CD205 (DEC-205) on page 47.
Novocastra Deleted in Colorectal
Cancer Protein
Clone DM51
1 mL lyophilized NCL-DCC P (HIER)
RUO*
RUO*
The deleted in colorectal cancer (DCC) gene located on chromosome 18 is a
tumor suppressor gene that encodes a transmembrane protein structurally
similar to NCAM. The highest reported expression of this protein can be
found in axons of the central and peripheral nervous systems where it
functions as a netrin receptor required for the guidance of the developing
axons. The DCC gene is reported to be expressed in most epithelial tissues
where the protein may participate in the regulation of cell to cell or cell to
substratum interaction. In normal colon, DCC expression is restricted to the
mucosa with intense granular cytoplasmic staining in the crypts, particularly
in the goblet cells. Altered DCC expression may be the result of allelic loss
which is reported to occur in more than 70 percent of colorectal
carcinomas, localized mutations, aberrant splicing of transcripts or allelespecific
loss of transcripts. The DCC gene has also been reported to be
inactivated in pancreatic, gastric, breast, prostatic and brain cancers and
also in some leukemias. The expression of DCC protein is reduced in these
cancers by 36 to 50 percent. In astrocytic tumors and colorectal carcinomas
reduced expression of DCC protein is reported.
Human colonic adenocarcinoma: immunohistochemical staining for deleted in colorectal
cancer protein using NCL-DCC. Note granular cytoplasmic staining of malignant epithelial
cells. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.