QF0159 Marketing Release Record

Novocastra Lambda Light Chain
Clone SHL53 Reference Range
1 mL, 0.1 mL liquid NCL-L-LAM-578 P (HIER)
7 mL BOND ready-to-use PA0570 P (HIER)
Clone HP-6054
1 mL lyophilized NCL-LAM ASR
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Novocastra Lamin
Clone 636
1 mL lyophilized lamin A/C NCL-LAM-A/C F P (HIER) W
Antigen Background
The nuclear lamina is a karyoskeletal structure composed of intermediate
filament type proteins called lamins. It underlies the inner nuclear membrane
and confers mechanical stability to the nuclear envelope. The human lamina
consists of four major types of lamin, namely A, B1, B2 and C. The loss of lamin
A expression has been reported to occur in small cell lung cancers.
Product Specific Information
NCL-LAM-A/C reacts with lamins A and C in human, cow and pig tissues.
Novocastra Laminin
Clone LAM-89
0.5 mL lyophilized NCL-LAMININ F P (Enzyme)
Laminin is a large (850 kD) disulfide-bonded heterotrimer, cross-shaped,
glycoprotein which is organized within the meshwork of basement
membranes such as those associated with epithelia, surrounding blood
vessels, nerves and underlying pial sheaths of the brain. It is reported to be
expressed in the extracellular matrix in sites other than basement
membranes during early stages of development and is localized to specific
types of neurons in the central nervous system during both embryonic and
adult development. Laminin interacts with receptors on cell surfaces, an
interaction which results in changes in the behavior of cells such as
attachment to a substrate, migration and neurite outgrowth during
embryonic development and regeneration.
Human placenta: immunohistochemical staining for laminin using NCL-LAMININ. Note staining
of basement membranes of blood vessels. Paraffin section.
IVD
IVD
IVD
IVD
Novocastra Langerin
Clone 12D6
1 mL lyophilized NCL-LANGERIN P (HIER)
Antigen Background
Langerin is a type II transmembrane C-type lectin which has mannosebinding
specificity. It is a 40 kD protein restricted to Langerhans cells that is
involved in the internalization of cell surface material in these immature
dendritic cells. Dendritic cells are antigen-presenting cells that are required
for initiation of a specific T cell-driven immune response. These cells are
found in nonlymphoid tissue as immature cells whose primary function is to
capture antigen through specialized surface membrane endocytic structures
or through macropinocytosis. The dendritic cells migrate to secondary
lymphoid tissue and mature into efficient antigen presenting cells. A part of
the maturation process includes the loss of adhesion receptors such as Ecadherin
and the disappearance of Birbeck granules. Although Langerin is
reported to be located on the cell surface, it can be rapidly internalized
following ligand capture into Birbeck granules. In fact, Langerin is a potent
inducer of membrane superimposition and zippering leading to Birbeck
granule formation. In reports it has been suggested that the induction of
Birbeck granules is a consequence of the antigen-capture function of
Langerin allowing passage into these organelles and providing access to a
non-classical antigen processing pathway.
Human basal cell carcinoma: immunohistochemical staining for langerin using
NCL-LANGERIN. Note membrane and cytoplasmic staining of Langerhans cells within the
tumor. Paraffin section.
Novocastra LFA-2 (CD2)
Clone AB75
1 mL, 0.1 mL lyophilized NCL-CD2-271 P (HIER)
1 mL liquid NCL-L-CD2-271 P (HIER) IVD
7 mL ready-to-use RTU-CD2-271 P (HIER) IVD
See also CD2 (LFA-2) on page 32.
Novocastra LMP-1 (Epstein-Barr virus)
CS1, CS2, CS3, Clone CS4
1 mL, 0.1 mL lyophilized NCL-EBV-CS1-4 F P (Enzyme)
See also Epstein-Barr virus (LMP-1) on page 61.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
IVD
IVD
/77
Primary Antibodies