QF0159 Marketing Release Record
QF0159 Marketing Release Record
QF0159 Marketing Release Record
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Novocastra Epstein-Barr virus (LMP-1)<br />
Clone CS1/CS2/CS3/CS4 cocktail<br />
1 mL, 0.1 mL lyophilized NCL-EBV-CS1-4 F P (Enzyme)<br />
Antigen Background<br />
Epstein-Barr virus (EBV) is one of the eight known human herpes viruses and<br />
belongs to the Gammaherpes viriniae, the same subfamily as human<br />
herpesvirus type 8 (HHV-8). Herpes viruses have large double strand DNA<br />
genomes and are complex viruses often encoding over 35 proteins including<br />
enzymes involved in nucleic acid metabolism, DNA synthesis and protein<br />
processing in addition to viral structural proteins. These viruses are capable<br />
of entering a latent phase where the host shows no visible signs of infection<br />
and levels of infectious agent become very low. During latency, viral gene<br />
expression is restricted to only a few genes. Latent membrane protein (LMP-<br />
1) is a 60 kD protein encoded by the BNLF1 gene of EBV.<br />
Product Specific Information<br />
NCL-EBV-CS1-4 is a cocktail of four monoclonal antibodies; clones CS1, CS2,<br />
CS3 and CS4.<br />
Novocastra Epstein-Barr virus (nuclear<br />
antigen 2)<br />
Clone PE2<br />
1 mL, 0.1 mL lyophilized NCL-EBV-PE2 FW<br />
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is an EBV-encoded<br />
nuclear protein of 82 kD. EBNA2 is essential for growth transformation of<br />
B lymphocytes and has been shown to modulate the activity of several viral<br />
and cellular promoters.<br />
Novocastra E-Selectin (CD62E)<br />
RUO*<br />
Clone 16G4<br />
1 mL lyophilized NCL-CD62E-382 RUO*<br />
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is an EBV-encoded<br />
nuclear protein of 82 kD. EBNA2 is essential for growth transformation of<br />
B lymphocytes and has been shown to modulate the activity of several viral<br />
and cellular promoters.<br />
IVD<br />
Novocastra Estrogen Receptor<br />
Clone 6F11 Reference Range<br />
1 mL, 0.1mL lyophilized NCL-ER-6F11 F P (HIER) W C<br />
1 mL liquid NCL-L-ER-6F11 F P (HIER) W C IVD<br />
7 mL ready-to-use RTU-ER-6F11 F P (HIER) W IVD<br />
7 mL BOND ready-to-use PA0151 P (HIER) IVD<br />
Antigen Background<br />
Estrogen receptor (ER) content of breast cancer tissue is an important<br />
parameter in the prediction of prognosis and response to endocrine therapy.<br />
The introduction of highly specific monoclonal antibodies to ER has allowed<br />
the determination of receptor status of breast tumors to be carried out in<br />
routine histopathology laboratories.<br />
Product Specific Information<br />
Clone 6F11 is raised to the full length alpha form of the estrogen receptor<br />
molecule present on human ER antigen, located in the nucleus of ER positive<br />
normal and neoplastic cells. Clone 6F11 has been extensively tested (Bevitt D<br />
J et al. Journal of Pathology. 183 : 228-232 (1997)). Further publications exist<br />
that discuss the sensitivity of clone 6F11 (Kauffman O et al. Modern Pathology<br />
11(4):357-363 (1998)) and Kaplan P A et al. American Journal of Clinical<br />
Pathology 123: 276-280 (2005). NCL-ER-6F11/2 and NCL-L-ER-6F11/2 are more<br />
economic options for high volume users of clone 6F11.<br />
Human breast carcinoma: immunohistochemical staining for estrogen receptor using<br />
NCL-L-ER-6F11. Note intense nuclear staining of tumor cells. Paraffin section.<br />
Novocastra Estrogen Receptor (beta)<br />
Clone EMR02<br />
1 mL lyophilized NCL-ER-beta ASR<br />
Analyte Specific Reagent. Analytical and performance characteristics are<br />
not established.<br />
F Frozen I Immunofluorescence E Electron microscopy<br />
P Paraffin C Flow cytometry O Other applications<br />
W Western blotting<br />
IVD<br />
/61<br />
Primary Antibodies
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