QF0159 Marketing Release Record

Primary Antibodies
Chronically inflamed human bronchus: immunohistochemical staining for CD38 antigen using
NCL-CD38-290. Note intense membrane staining of infiltrating activated T lymphocytes.
Paraffin section.
Novocastra CD39
Clone 22A9
1 mL lyophilized NCL-CD39 P (HIER)
CD39 antigen is a transmembrane glycoprotein found on mature
B lymphocytes, follicular dendritic cells, endothelial cells, activated T cells,
NK cells and Langerhans cells. It is also known as E-type apyrase which
hydrolyses extracellular ATP and ADP, a function important to homotypic
adhesion and platelet aggression. CD39 antigen expressing cells may
provide protection from the toxic effects of ATP leaked from damaged cells.
CD39 antigen may enable tumor cells to reduce contact with T lymphocytes
and escape immunological recognition. Increased levels of CD39 antigen
expression are also reported to be associated with increased ectoATPase
activity that occurs during the progression of melanomas.
Human lymph node, B cell lymphoma: immunohistochemical staining for CD39 antigen using
NCL-CD39. Note intense membrane staining of tumor cells. Paraffin section.
Novocastra CD41 (GPIIb/IIIa)
Clone M148
1 mL lyophilized NCL-CD41 F
The CD41 antigen, also known as GPIIb/IIIa, is reported to be expressed
early in megakaryocyte maturation and in megakaryoblastic leukemias and
is absent or defective in platelets from patients with Glanzmann's thrombasthenia.
The CD41 antigen is involved in fibrinogen binding, clot retraction
and platelet aggregation.
/40
RUO*
RUO*
For detailed information on all products please visit our website:
www.leica-microsystems.com
Human tonsil: immunohistochemical staining for CD41 antigen (GPIIb/IIIa) using NCL-CD41.
Note staining of aggregated platelets within the blood vessel. Frozen section.
Novocastra CD42b (GPIb)
Clone MM2/174
1 mL lyophilized NCL-CD42b F P (HIER)
Antigen Background
The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetininduced
aggregation and is involved in the binding of platelets to blood vessel
walls. The CD42b antigen is reported to be expressed on platelets and on
megakaryocytes in bone marrow and in megakaryoblastic leukemias. The
absence of CD42b antigen on platelets is reported to be a possible indicator
of Bernard-Soulier disease.
Novocastra CD43
Clone MT1
1 mL lyophilized NCL-MT1 F P (Enzyme) W
1 mL liquid NCL-L-MT1 F P (Enzyme) W IVD
7 mL ready-to-use RTU-MT1 F P (Enzyme)
7 mL BOND ready-to-use PA0938 P (HIER)
Novocastra CD44 Variant Antibodies
Clone VFF-327v3
1 mL lyophilized CD44 variant 3 NCL-CD44v3 F P (HIER) W
RUO*
Clone VFF-7
1 mL lyophilized NCL-CD44v6 F P (HIER)
The CD44 molecule belongs to a family of cellular adhesion molecules found
on a wide range of normal and malignant cells in epithelial, mesothelial and
hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are
normally expressed to encode the basic CD44 (H-CAM) molecule. The
additional 10 exons (v1 to v10) are only expressed by alternative splicing of
the nuclear RNA. The expression of specific cell adhesion molecule CD44
splice variants has been reported to be associated with metastasis in
certain human malignancies, such as breast cancer. A complex pattern of
CD44 variant expression in different tumors compared to the CD44
expression of the normal cell of origin has been reported (Fox SB et al.,
Cancer Research (53): 4539-4546, (1994)). High levels of expression were
observed with the variant exons by breast carcinomas that arise from breast
ductal epithelium which do not normally express CD44. Conversely, normal
gastrointestinal epithelium were reported to express low levels of many of
the CD44 variants and the derived colon cancers expressed low and
variable levels of the variants. Respiratory epithelium which expressed
variants at high levels in normal cells were reported to express the same
variants at similar levels in lung carcinomas.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
IVD
RUO*
RUO*
RUO*
IVD