QF0159 Marketing Release Record

Origin
CD8
Clone 1A5
50 Tests ORG-8936
Antigen Background
The CD8 molecule is composed of two chains and has a molecular weight of
32 kD. It has been found on a subset of normal cytotoxic/suppressor cells
which make up approximately 20-35 percent of human peripheral blood
lymphocytes. The CD8 molecule is reported to be detected on natural killer
cells, 80 percent of thymocytes, on a sub-population of 30 percent of
peripheral blood null cells and 15-30 percent of bone marrow cells.
Product Specific Information
T cell disorders may be characterized using Origin CD8 (Clone 1A5) as part of
a panel of antibodies.
Refer to page 34 for further information about Clone 1A5.
Origin CD8 (Clone 1A5) on tonsil. Paraffin section.
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CD10
Clone 56C6
50 Tests ORG-8941
Antigen Background
IVD IVD
CD10 antigen is also known as neprilysin and common acute lymphoblastic
leukemia antigen (CALLA). CD10 antigen is expressed on a wide variety of
normal and neoplastic cells.
Product Specific Information
CD10 expression is reported on cells of lymphoblastic, Burkitts’ and follicular
lymphomas and on B cells from patients with chronic myelocytic leukemia, as
such, Origin CD10 (Clone 56C6) may be used in the differential diagnosis of
small B cell lymphoma and the subtyping of lymphoblastic leukemia.
Refer to page 35 for further information about Clone 56C6.
Origin CD10 (Clone 56C6) on lymphoma. Paraffin section.
CD23
Clone 1B12
50 Tests ORG-8826
Antigen Background
IVD
The CD23 antigen, a membrane glycoprotein of 45 kD, is reportedly found on
a subpopulation of peripheral blood cells, B lymphocytes and on EBVtransformed
B lymphoblastoid cell lines. The CD23 molecule is also known as
the low affinity IgE receptor found on B cells. Expression has been reported
on neoplastic cells from B cell chronic lymphocytic leukemias and
centrocytic/centroblastic lymphomas.
Product Specific Information
Origin CD23 (Clone 1B12) is recommended for use in the differential diagnosis
of small B cell lymphomas.
Refer to page 38 for further information about Clone 1B12.
Origin CD23 (Clone 1B12) on tonsil. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.