QF0159 Marketing Release Record

Primary Antibodies
Human squamous cell carcinoma: immunohistochemical staining for gamma-catenin using
NCL-G-CAT. Note intense membrane staining of malignant epidermal cells. Paraffin section.
Novocastra GAP43
Clone 1G7
1 mL lyophilized NCL-GAP43 P
Growth associated phosphoprotein 43 (GAP43) is a major protein of neuronal
growth cones and certain presynaptic terminals. It is a candidate for
involvement in both axon growth and synaptic plasticity. It has been
reported that in several neuronal systems, GAP43 expression is higher in
neurons that are extending axons, either during development or
regeneration of injured axons found in intact adult neurons. GAP43 is the
best characterized of the growth associated proteins and although its
normal action in vivo is unclear, GAP43 can bind calmodulin, inhibit
phosphatidylinositol phosphate kinase, be phosphorylated by protein kinase
C, affect neurotransmitter release and enhance filopodia in non-neuronal
cells.
Human brain, normal adult cerebral cortex: immunohistochemical staining for growth
associated protein 43 using NCL-GAP43. Note intense staining of neurons and apical
dendrites. Paraffin section.
Novocastra Gastrin
Polyclonal
7 mL BOND ready-to-use PA0681
/66
RUO*
Antigen Background
Gastrin, a polypeptide hormone, occurs naturally in three forms: gastrin-14,
gastrin-17 and gastrin-34. Both primary and secondary G cell hyperplasia are
reported to be characterized by clustering of the immunoreactive cells which
sometimes project buds from the mucous glands.
IVD
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Normal human stomach: immunohistochemical staining for gastrin using NCL-GASp.
Note intense cytoplasmic staining of the gastric mucosa. Paraffin section.
Novocastra Geminin
Clone EM6
1 mL liquid NCL-L-Geminin P (HIER)
Geminin is a protein of 209 amino acids thought to be involved in the control
of DNA replication via the interaction with Cdt1. Geminin is not found in the
G1 phase of the cell cycle, but is first expressed in the G1 to S transition
phase, with expression levels rising through the rest of the cell cycle and
levels reaching a maximum during mitosis. It has been proposed that
Geminin may be a tumor suppressor protein. Geminin is reported to be
expressed in proliferating lymphocytes and epithelial cells eg germinal
centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of
the testes, within the basal layers of the squamous epithelium of the skin
and breast. Geminin is reported to be upregulated in cancers such as non-
Hodgkin’s lymphoma, B cell lymphoma, breast carcinoma and colon
carcinoma.
Human chronic lymphocytic leukemia: immunohistochemical staining for Geminin using
NCL-L-Geminin. Note intense nuclear staining of proliferating neoplastic cells. Paraffin section.
Novocastra Giardia intestinalis
Clone 9D5.3.1
1 mL lyophilized NCL-GI P (HIER)
RUO*
Giardia intestinalis (formerly Giardia lamblia) is a flagellated protozoan,
which infects humans via contaminated water supplies, causing illnesses
ranging from acute severe bloody diarrhoea, through moderate enteritis,
chronic diarrhoea with malabsorption, to asymptomatic excretion. The
remarkable hardiness of the cyst form and the low numbers required to
infect make the epidemiology uncertain, although water-based infections
are the most common.
IVD
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.