QF0159 Marketing Release Record

Primary Antibodies
Novocastra Human Follicle Stimulating
Hormone (beta 2) (HFSH)
Clone INN-HFSH-60
1 mL lyophilized NCL-HFSH F P (Enzyme)
7 mL BOND ready-to-use PA0693 P IVD
Novocastra Human Gastric Mucin
(HGM-45M1)
Clone 45M1
1 mL, 0.1 mL lyophilized NCL-HGM-45M1 F P (HIER)
Many of the cancer associated antigens have been identified as mucin
antigens. The expression of these antigens are associated with the earliest
steps in mucin glycosylation which in turn is associated with several
diseases. Human Gastric mucin is found on the surface of gastric epithelium
of the normal gastrointestinal tract. The “gastric mucins” include Muc-1,
Muc-5AC and Muc-6 glycoproteins.
Product Specific Information
NCL-HGM-45M1 recognizes the mucin epitope located in the peptide core of
gastric mucin, fulfilling a similar function to the antibody, NCL-MUC-1-CORE.
Thiol reduction (using 2-mercaptoethanol) completely destroys this epitope,
which is partially lost following trypsin proteolysis but is stable upon
periodate oxidation.
Novocastra Human Growth Hormone
(HGH)
Polyclonal
0.25 mL lyophilized NCL-HGH FP
7 mL BOND ready-to-use PA0704 P
Growth hormone (GH), somatotropin, is the primary hormone responsible for
regulating overall body growth and is also important in organic metabolism.
It is synthesized by acidophilic or somatotropic cells of the anterior pituitary
gland. Human GH has a molecular weight of 22 kD. GH stimulates growth
indirectly by promoting the liver's production of somatomedins, which act
directly on bone and soft tissue to cause growth. GH exerts direct metabolic
effects on the liver, adipose tissue and muscle. In general, growth hormone
enhances protein synthesis, conserves carbohydrates and uses up fat
stores.
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IVD
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IVD
RUO*
RUO*
Novocastra Human Herpesvirus (type 8)
(latent nuclear antigen)
Clone 13B10
1 mL, 0.1 mL lyophilized NCL-HHV8-LNA P (HIER) W
Antigen Background
Human herpesvirus type 8 (HHV8), is the proposed etiological agent of
Kaposi's sarcoma (KS). It is reported that HHV8 has been demonstrated in KS
tissues by immunohistochemistry, in situ PCR and also in situ hybridization.
HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral
gene orf 73. LNA is capable of forming a complex with retinoblastoma
susceptibility gene product which may be related to its oncogenic activity.
HHV8 has been reported to be expressed in multicentric Castleman's disease
(MCD) and in angioimmunoblastic lymphadenopathies. The localization of
HHV8 in subcapsular spindle cell proliferations, which is where early
intranodal KS begins, and endothelial cells in Castleman's disease may
explain the link between intranodal KS and MCD. In MCD, HHV8 is reported to
be expressed in mantle zone large immunoblastic B cells.
Human Kaposi's sarcoma: immunohistochemical staining for HHV8 latent nuclear antigen
using NCL-HHV8-LNA. Note nuclear staining in a proportion of infected tumor cells. Paraffin
section.
Novocastra Human Neutrophil
Defensins (1/2/3)
Clone D21
1 mL lyophilized NCL-DEFENSIN P (HIER)
Defensins are antimicrobial agents which together with serprocidins,
lysozyme, bacterecins, protegrins and indolicidin have been isolated from
neutrophil and macrophage granules. Defensins are synthesized as 93 to 96
amino acid pre-propeptides. In fully differentiated phagocytes, virtually all of
the cellular defensin exists as processed mature peptide. Neutrophil
defensins are stored in azurophil granules which discharge their contents
into microbe-containing phagosomes through the process of phagosome/
granule fusion. Paneth cells of the small intestine are also reported to
secrete defensins, as well as lysozyme into the crypt lumen which may limit
local microbial proliferation and colonization. These peptides may also exert
chemotactic and immunomodulating effects in host defence and
inflammation. The three principle human neutrophil defensin peptides, HNP
1, 2 and 3, are reported to be unique to neutrophils and account for 99
percent of the defensin content in these cells. Activation of neutrophils
leads to a rapid release of HNP which may also be measured in plasma and
other body fluids in infection and inflammation.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
RUO*
IVD