QF0159 Marketing Release Record

Primary Antibodies
Novocastra Varicella-zoster virus
Clone C90.2.8
1 mL lyophilized Varicella-zoster virus NCL-VZV PI
Antigen Background
Varicella-zoster virus is a member of the alphaherpesvirinae. It is responsible
for two ubiquitous diseases: varicella (chickenpox), an exanthem of
childhood, and herpes zoster (shingles), a disabling disease of the elderly and
immunocompromised individuals.
Product Specific Information
NCL-VZV is specific for Varicella-zoster virus and does not cross-react with
Respiratory syncytial virus, Parainfluenza virus types 1, 2, 3 and 4b,
Adenovirus, Herpes simplex virus types 1 and 2, Influenza virus types A and
B, Mumps virus, Measles virus, echovirus 19, Coxsackie B4 virus and
Poliovirus types 1, 2 and 3.
Human skin: immunohistochemical staining for Varicella-zoster virus using NCL-VZV.
Note staining of infected cells within a vesicle. Paraffin section.
Novocastra Vascular Endothelial
Growth Factor Receptor-3
Clone KLT9
1 mL liquid NCL-L-VEGFR-3 ASR
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Novocastra VE-Cadherin (CD144)
Clone 33E1
1 mL liquid NCL-L-VE-Cad P (HIER)
Vascular endothelial cadherin (VE-Cadherin) is a calcium dependant
molecule involved in the adhesion cells to the extracellular matrix. VE-
Cadherin is localized to the intracellular junctions of endothelial layers, such
as those of blood and lymphatic vessels and placenta. VE-Cadherin is
unique among the adherin proteins as it is expressed only in the endothelial
layers. VE-Cadherin has been reported to be used to identify tumors derived
from endothelial tissue.
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IVD
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RUO*
Human angiosarcoma: immunohistochemical staining for VE-Cadherin using NCL-L-VE-Cad.
Note staining of malignant endothelial cells. Paraffin section.
Novocastra Vesicular Monoamine
Transporter (VMAT) 1
Clone RMT77
1 mL liquid Vesicular Monoamine Transporter 1
(VMAT1) NCL-L-VMAT1 P (HIER) IVD
Vesicular monoamine transporters (VMAT1 and VMAT2) mediate
monoamine accumulation from the cytoplasm into storage organelles. They
are dependent on a vacuolar ATPase-generated proton gradient to transport
the cationic amine substrates into the storage organelle in exchange for
protons. VMAT1 is a glycoprotein, located in the membranes of secretory
granules/vesicles and is expressed in enterochromaffin (EC) cells and
adrenal chromaffin cells. The presence of secretory vesicles is reported in
tumor cells and is regarded as evidence of neuroendocrine differentiation.
Demonstration of secretory granules in tumor cells has been reported using
electron microscopy or immunohistochemistry. Specific hormone production
cannot always be demonstrated in endocrine tumors, whose origin and
biological behavior may be difficult to determine. Vesicular monoamine
transporter (VMAT2) mediates the monoamine accumulation from the
cytoplasm into storage organelles and is located in the membranes of the
secretory granules/vesicles. VMAT2 is reported to be coexpressed in all
chromaffin cells of the adrenal medulla. It is also reported to be expressed in
gastric enterochromaffin-like cells, beta cells of the pancreas, Langerhans
cells of the skin and a population of central, peripheral and enteric neurons.
Human infiltrating carcinoid of the bowel: immunohistochemical staining for vesicular
monoamine transporter 1 (VMAT1) using NCL-L-VMAT1. Note intense cytoplasmic staining
of malignant cells. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.