QF0159 Marketing Release Record
QF0159 Marketing Release Record
QF0159 Marketing Release Record
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Origin<br />
bcl-2 Oncoprotein<br />
Clone bcl-2/100/D5<br />
50 Tests ORG-8714<br />
Antigen Background<br />
Bcl-2 antigen is a member of a family of proteins that are involved in<br />
apoptosis. The antigen is an integral inner mitochondrial membrane protein<br />
of 25 kD and has wide tissue distribution. It is considered to act as an inhibitor<br />
of apoptosis. For this reason bcl-2 expression is inhibited in germinal centers<br />
where apoptosis forms part of the B cell production pathway. In 90 percent of<br />
follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene<br />
at 18q21, to an immunoglobulin gene, with subsequent deregulation of gene<br />
expression and cell proliferation.<br />
Product Specific Information<br />
Origin bcl-2 (Clone bcl-2/100/D5) is recommended for use in the differentiation<br />
of lymphomas from reactive lymph nodes.<br />
Refer to page 24 for further information about Clone bcl-2/100/D5.<br />
Origin bcl-2 (Clone bcl-2/100/D5) on tonsil. Paraffin section.<br />
/ 134<br />
For detailed information on all products please visit our website:<br />
www.leica-microsystems.com<br />
CD1a<br />
Clone JPM30<br />
50 Tests ORG-8968<br />
IVD IVD<br />
Antigen Background<br />
CD1a is a protein of 43 to 49 kD expressed on dendritic cells and cortical<br />
thymocytes. CD1a antigen expression has been shown to be useful in<br />
differentiating Langerhans cells, powerful antigen presenting cells present in<br />
skin and epithelia, from interdigitating cells. Immunohistochemical studies for<br />
CD1a antigen have reported a reduction in epidermal Langerhans cells in<br />
graft versus host disease and the participation of CD1a in atherosclerotic<br />
lesion formation and asthmatic inflammation.<br />
Product Specific Information<br />
Origin CD1a (Clone JPM30) is recommended for use in detecting CD1a protein<br />
expression in a variety of normal and neoplastic tissues, including<br />
Langerhans’ cell histiocytosis and thymomas.<br />
Refer to page 32 for further information about Clone JPM30.<br />
Origin CD1a (Clone JPM30) on skin. Paraffin section.<br />
Products in this catalog are subject to regulatory approval.<br />
Please consult your Leica Microsystems representative for availability in your region.<br />
* For Research Use Only. Not for use in diagnostic procedures.
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