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Epidemiology of Inhalant Abuse - Archives - National Institute on ...

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FIGURE 5. United Kingdom VSA-related deaths: Average annual<br />

death rate per milli<strong>on</strong>, 1983-1991 (ages 10-24).<br />

differences in neurochemical acti<strong>on</strong>s and clinical pr<str<strong>on</strong>g>of</str<strong>on</strong>g>iles. Alkyl nitrites<br />

should be differentiated from compounds used for VSA for those reas<strong>on</strong>s.<br />

However, they have been included here in order to emphasize the<br />

difference in mortality: Only 5 <str<strong>on</strong>g>of</str<strong>on</strong>g> 1,237 United Kingdom VSA-related<br />

deaths involve alkyl nitrites, all in males over 30 years old. However, no<br />

reas<strong>on</strong> is apparent for exclusi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the volatile anesthetics since the mode<br />

<str<strong>on</strong>g>of</str<strong>on</strong>g> acti<strong>on</strong> is similar to the other compounds used in VSA. If this strategy<br />

were adopted, it would be difficult to decide whether to exclude<br />

trichloroethylene, chlor<str<strong>on</strong>g>of</str<strong>on</strong>g>orm, and diethyl ether, all <str<strong>on</strong>g>of</str<strong>on</strong>g> which have been<br />

214

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