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CONTENT
Content
General Remarks 6
Abbreviations Used 7
PART – A STUDIES ON 2-METHYL INDOLINE DERIVATIVES
A.1 Introduction to indole system 12
A.1.1 Physical properties of indole 12
A.2 Introduction to indoline system 13
A.2.1 Reduction of indole 13
A.2.2 Preparation of 2-methyl indoline 17
A.2.3 N-alkylation on 2-methyl indoline 19
A.2.4 Mannich reaction on 2-methyl indoline 26
A.3 References 27
CHAPTER – 1 PREPARATION AND YIELD OPTIMIZATION OF 2-
METHYL INDOLINE AND STUDY OF MANNICH
REACTION ON 2-METHYL INDOLINE MOIETY
1.1 Aim of current work 34
1.2 Reaction scheme 36
1.3 Plausible reaction mechanism 38
1.4 Experimental 40
1.5 Physical data tables 44
1.6 Spectral discussion 46
1.6.1 Mass spectral study 46
1.6.2 IR spectral study 49
1.6.3 1 H & 13 C NMR spectral study 49
1.6.4 Elemental analysis 53
1.7 Analytical data 53
1.8 Results and discussion 58
1.9 Conclusion 59
1.10 Spectral representation of synthesized compounds 60
Department of Chemistry, Saurashtra University, Rajkot – 360 005 1