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Chapter – 3 Preparation of small library…..
3.2 REACTION SCHEMES
3.2.1 PREPARATION OF METHYL-2-PROPYLPENTANOATE
C
H 3
C
H 3
Reagents / Reaction Condition (a): Methanol, Con. H2SO4 / Reflux, 12-14
hours.
3.2.2 PREPARATION OF 2-PROPYLPENTANOHYDRAZIDE
C
H 3
C
H 3
O
O
OH
O CH 3
C
H 3
C
H 3
Reagents / Reaction Condition (b): Hydrazine hydrate / Reflux, 12-14 hours.
3.2.3 PREPARATION OF ISATIN-N-MANNICH BASES
N
H
O
O
a
b
c
C
H 3
C
H 3
Reagents / Reaction Condition (c): Isatin, 50% Ethanol, Formaldehyde (37-
41%) / 0-5°C.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 149
R 1
N
N
R 2
O
O
O CH 3
O
NH NH 2
O