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Summary Synthesis and biological profile…..
SUMMARY
The work represented in the thesis entitled “Synthesis and biological profile of
some novel heterocyclic moieties bearing Nitrogen, Sulphur and Oxygen
atoms” is divided into six chapters which can be summarized as under.
Chapter – 1 deals with the 2-methyl indoline derivatives. Being an
analogue of indole nucleus, 2-methyl indoline is having diversified biological
profile. It was decided to explore new chemistry involving 2-methyl indoline
moiety and to carry out their biological evaluation.
Synthesis and yield optimization of the 2-methyl indoline was carried
out in Chapter – 1. Literature survey revealed that different types of Nalkylation
reactions have been carried out on 2-methyl indoline but only one
reaction is reported for Mannich reaction on 2-methyl indoline, where
benzotriazole was used as a secondary amine along with formaldehyde (37-
41% w/w solution). So looking to the unreported chemistry aspect, different
secondary amines and primary aromatic amines were selected to carry out
Mannich reaction on 2-methyl indoline in order to acquire N-Mannich bases.
Importance of microwave irradiation in organic synthesis has been
described in Chapter – 2. Chapter – 2 is also dealing with different 2-methyl
indoline derivatives and isatin derivatives. Literature survey revealed that Nalkylation
with the chain having three carbon atoms and different secondary
amines at another end has not been reported using indoline and isatin
nucleus so far. Thus N-alkylation with different alkyl chains and their biological
evaluation was the aim behind the work done in this chapter.
The synthesis of pyrazoles remains of great interest owing to the wide
applications in pharmaceutical for their analgesic, antipyretic, antibacterial and
anti-inflammatory properties. Chapter – 3 is consisting study of different types
of reactions involving pyrazole aldehyde as a chemically reactive component.
In this chapter, five different pyrazole aldehydes were synthesized and
reacted with 1-(2, 6-dichlorophenyl)-2-indolinone, 3-acetyl-4-
Department of Chemistry, Saurashtra University, Rajkot – 360 005. 347