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Part – B Studies on isatin derivatives…..
Fig. B.1.17
Pandeya et. al. 248 synthesized Mannich bases of norfloxacin by
reacting them with formaldehyde and several isatin derivatives. The starting
materials 3-[4-sulfadiazinimino] isatin, 3-[4(-sulfadoximino] isatin and 3-[4'amino,
5'-(3'', 4'', 5''-trimethoxybenzyl)pyrimidin-2'-yl]imino isatin and their 5substituted
derivatives were prepared by reacting isatin and its derivatives
with sulfadiazine, sulfadoxine and trimethoprim in the presence of glacial
acetic acid. Mannich bases of norfloxacin were prepared by condensing the
active hydrogen atom of isatin and the secondary amino function (piperazino
moiety) of norfloxacin. (Fig. B.1.18)
Fig. B.1.18
Korepin et. al. 249 reported Mannich reactions of amino alchohols 3aminopropan-1-ol
or 2-aminoethanol with formaldehyde and C-H or N-H acids
gave N-substituted tetrahydro-1, 3-oxazines or oxazolidines. Thus, reaction
Department of Chemistry, Saurashtra University, Rajkot-360 005 125