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Chapter – 1 Preparation and Yield optimization..... 0.015 mole of formaldehyde (37-41% w/w solution) and 10 ml diethylether were added into above flask and the mixture was magnetically stirred for some time at room temperature under acidic condition. 0.01 mole of an appropriately substituted primary amine was added drop wise into above reaction mixture. Stirring was continued for further half an hour at room temperature. The progress and the completion of the reaction were checked by silica gel-G F254 thin layer chromatography using hexane : ethyl acetate (9 : 1) as a mobile phase. After the reaction to be completed, the reaction mixture was extracted using ethyl acetate (30 ml X 3). The combined organic layer was washed using water (20 ml X 2). The organic layer was dried over anhydrous sodium sulphate and the solvent was removed under reduced pressure to acquire the product. (Physical data of the synthesized end products are summarized in the table 1.5.2) Department of Chemistry, Saurashtra University, Rajkot-360 005 43
Chapter – 1 Preparation and Yield optimization..... 1.5 PHYSICAL DATA TABLES 1.5.1 Physical data of N-substituted 2-methyl indoline N-Mannich bases (DNJ-101 to DNJ-111) Code Substitution R1 & R2 Department of Chemistry, Saurashtra University, Rajkot-360 005 44 MF MW (g/m) Rf % Yield DNJ-101 Piperidine C15H22N2 230 0.54 55 DNJ-102 Morpholine C14H20N2O 232 0.52 61 DNJ-103* Piperazine C14H21N3 231 0.53 75 DNJ-104 1-methyl piperazine C15H23N3 245 0.55 77 DNJ-105 1-ethyl piperazine C16H25N3 259 0.57 65 DNJ-106 Pyrrolidine C14H20N2 216 0.51 50 DNJ-107 1-benzyl piperazine C21H27N3 321 0.63 79 DNJ-108 N, N-dimethyl amine C12H18N2 190 0.49 67 DNJ-109 N, N-diethyl amine C14H22N2 218 0.52 56 DNJ-110 N, N-dipropyl amine C16H26N2 246 0.56 72 DNJ-111 N, N-dibutyl amine C18H30N2 274 0.60 49 Rf value was calculated using solvent system = Hexane : Ethyl Acetate (9 : 1) * MP = 160-162°C R 1 N N R 2 CH 3
Page 1 and 2: Saurashtra University Re - Accredit
Page 3 and 4: Statement under O. Ph. D. 7 of Saur
Page 6 and 7: ACKNOWLEDGEMENT It is a moment of g
Page 8 and 9: Jignesh Lunagariya, Hitesh Sarvaiya
Page 10 and 11: CONTENT Content General Remarks 6 A
Page 12 and 13: Content 3.2 Reaction scheme 149 3.3
Page 14 and 15: 5.14 Conclusion 313 5.15 Spectral r
Page 16 and 17: MF Molecular Formula MW Molecular W
Page 18 and 19: GABA Gamma Amino Butyric Acid MES M
Page 20 and 21: PART - A STUDIES ON 2-METHYL INDOLI
Page 22 and 23: Part-A Studies on 2-methyl indoline
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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