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Chapter – 3 Preparation of small library…..
3.8 RESULTS AND DISCUSSION
Mannich bases and Schiff bases of isatin were prepared in this
chapter. Isatin is known to produce N-Mannich bases using formaldehyde and
secondary amines while it is known to give 3-substiuted Schiff bases when
reacted with primary amine.
Isatin-N-Mannich bases were prepared using the known methodology
and their Schiff bases were prepared using two different primary amine
functional groups, one is 2-propylpentanohydrazide and another is 2aminobenzothiazole.
2-propylpentanohydrazide was prepared by reacting
hydrazine hydrate with Methyl-2-propylpentanoate and 2-propylpentanoate
was prepared by the esterification of 2-propylpentanoic acid which is also
known as very well known anticonvulsant drug “Valproic acid”. 2aminobenzothiazoles
also possess varied biological profile. Thus two
biologically active components were substituted on isatin to study the
biological activity profile of title compounds.
Schiff base of isatin using 2-propylpenanohydrazide is not reported so
far while Schiff base of isatin and 2-aminobenzothiazole is not much explored.
Moreover Mannich bases of these Schiff bases are not reported so far.
Furthermore acetylation was carried out on isatin-Schiff bases. Thus it is first
attempt to prepare three different types of indolinone derivatives and their
anticancer evaluation.
The compounds prepared in this chapter possess indole nucleus and
are basically indolinone derivatives. Indoles and indolinones are very well
known for their anticancer activity. Thus all the compounds were screened for
their anticancer activity against three different cancer cell lines. (viz. breast,
lung and stomach) All the compounds found to be good to moderate active
against all the three cancer cell lines.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 176