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Part – B Studies on isatin derivatives…..
Fig. B.1.14
Popp and Rajopadhye 245 prepared the title compounds by the
cyclocondensation of thiolactic acid with isatin-3-imines. 5'-methyl-3'-phenylspiro
[3H-indole-3, 2'-thiazolidine]-2, 4' (1H)-dione has been subjected to the
Mannich condensation to give 1-substituted derivatives. (Fig. B.1.15)
Fig. B.1.15
Further they 246 synthesized Mannich base of 3'-(4-chlorophenyl)-5, 5'dimethyl-4'H-spiro[indole-3,
2'-[1, 3]thiazolidine]-2, 4'(1H)-dione using
formaldehyde and morpholine along with differently substituted isatin
derivatives. (Fig. B.1.16)
Fig. B.1.16
Varma and Singh 247 prepared differently substiuted isatins and then
they reported Mannich bases of afore mentioned isatins. (Fig. B.1.17)
Department of Chemistry, Saurashtra University, Rajkot-360 005 124