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Chapter – 6 Biological evaluation of newly..... compound having piperidine subunit (i.e. DNJ-1402) was found to be moderate active against stomach cancer cell line while it was found to be less active against rests of the two cancer cell lines. Moreover the compound having N-benzyl piperazine subunit (i.e. DNJ-1405) was found to be moderate active against lung cancer cell line while it was found to be less active against rests of the two cancer cell lines. The compound having N-methyl piperazine subunit (i.e. DNJ-1403) was found to possess less cytotoxic activity against all the three cancer cell lines while the compound having N-ethyl piperazine subunit (i.e. DNJ-1404) was found to possess moderate cytotoxic activity against stomach and breast cancer cell lines and less cytotoxic activity against lung cancer cell line. In case of DNJ-1501 to DNJ-1505, DNJ-1501 was found to possess less cytotoxic activity against all the three cancer cell lines. DNJ-1502 was found to be good active against stomach cancer cell line with the ED50 value 39 µg/ml while it was found to be less active against rests of the two cancer cell lines with the ED50 value more than 100 µg/ml. DNJ-1503 and DNJ-1504 were found to possess less cytotoxic activity against stomach (ED50 : >100 and 89 µg/ml respectively) and lung cancer (ED50 : >100 µg/ml) cell lines while they were found to possess moderate cytotoxic activity (ED50 : 81 and 61 µg/ml respectively) against breast cancer cell line. DNJ-1505 was found to be good active (ED50 : 30 µg/ml) against stomach cancer cell line while it was found to be moderate active against breast (ED50 : 50 µg/ml) and lung (ED50 : 84 µg/ml) cancer cell lines. Thus from above results it could be summarized that the compound having no substitution in benzothiazole subunit (i.e. DNJ- 1501) found to be less active against all the three cancer cell lines. Furthermore the compound having methoxy group at 6 th position in benzothiazole subunit (i.e. DNJ-1502) was found to be good active against stomach cancer cell line while it was found to be less active against rests of the two cancer cell lines. Moreover the compounds having halogen group (i.e. Cl and F) at 6 th position in benzothiazole subunit (i.e. DNJ-1503 and DNJ- 1504) were found to possess less cytotoxic activity against stomach and lung cancer cell lines while they were found to possess moderate cytotoxic activity against breast cancer cell line. The compound having nitro group at 6 th Department of Chemistry, Saurashtra University, Rajkot – 360 005 337
Chapter – 6 Biological evaluation of newly..... position on benzothiazole subunit was found to be good active against stomach cancer cell line while it was found to be moderate active against breast and lung cancer cell lines. Further study on other molecules is under progress. Department of Chemistry, Saurashtra University, Rajkot – 360 005 338
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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