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Part – B Studies on isatin derivatives…..
Esmaeili et. al. 258 prepared N-Mannich bases of isatin by refluxing
isatin, formaldehyde and secondary amine in tetrahydrofuran.
Tiwari et. al. 259 synthesized 5-substituted-3-{4'-(3''-chlorobenzyloxy)benzoyl
hydrazono}-2-indolinones by the condensation of 4-(3'chlorobenzyloxy)-benzoylhydrazine
and 5-substituted isatins. Mannich
reaction in the presence of formaldehyde and heterocyclic secondary amines
on indolinones furnished 1-aminomethyl-5-substituted-3-{4'-(3''chlorobenzyloxy)-benzoyl
hydrazono}-2-indolinones. (Fig. B.1.29)
Where, R1 = H, Me, Br, Cl
R 1
N
H
O
R2 = Morpholine, Piperidine, Pyrrolidine, N-Me-Piperazine
N NH
O
O
Fig. B.1.28
Cl
N O
Department of Chemistry, Saurashtra University, Rajkot-360 005 130
R 1
R 2
Fig. B.1.29
N
NH
O
O
Cl