Download (4Mb) - Etheses - Saurashtra University

Part – B Studies on isatin derivatives…..
NaOH and R 2 CH2CH2Cl.HCl gave 61-73 % (3) (R 2 = morpholino, piperidino,
pyrrolidino). (Fig. B.1.12)
Collino and Volpe 242 prepared Mannich bases from benzimidazoles,
benzotriazoles, indolones, or benzoxazolones and N-phenylpiperazine, 4anilinopiperidine,
4-benzylpiperidine, or N-bezylpiperazine.
R 1
R 1
N
R
X
O
N
H
I
N
N
N
S CH 2CH 2R 2
The same authors 243 further prepared Mannich bases of N
heterocycles or aromatic amines with trimethylenedipiperidine, dipiperidine,
and hydroxyethyldipiperidine as well as the isatin derivatives (where, n = 6, 7).
(Fig. B.1.13)
N
1
O
3
O
O
O
N
CO(CH 2 )nCO
I
R 1
244
Jancevska-Nikolovska converted the hexylbenzene into 4hexylaniline
which underwent cyclization reactions to give acridines,
benzacridines, isatins, carbazoles, indoles, benzindoles, quinolines, and
benzoquinolines. (all substituted with the hexyl group) Further they carried out
Mannich reaction to give N-substituted derivatives. (Fig. B.1.14)
Department of Chemistry, Saurashtra University, Rajkot-360 005 123
2
Fig. B.1.12
Fig. B.1.13
N
H
N NH
N
III
S
II