Download (4Mb) - Etheses - Saurashtra University

More documents

Recommendations

Info

Chapter – 6 Biological evaluation of newly..... samples and positive and negative controls, were incubated at 37C for 16-18 hours. The wells were visually inspected for growth and were also reat at 630 nm by Automated Micropalte Reader [(EL800) Trinity Biotech] and the MICs were recorded as the lowest concentration of drug which inhibits the growth of bacteria. MIC (Minium Inhibitory Concentration in vitro activity µg/ml) values of DNJ- 101 to DNJ-111 and DNJ-201 to DNJ-210 ND = Not Done Sr. No. Representative Compound Bp Se Sp Sa1 Ef1 1 DNJ-101 0.5 1 4 8 2 2 DNJ-102 2 0.5 2 16 4 3 DNJ-103 4 4 1 32 2 4 DNJ-104 2 0.5 >16 >16 8 5 DNJ-105 2 2 8 4 >16 6 DNJ-106 4 1 2 ND 32 7 DNJ-107 2 4 1 >8 16 8 DNJ-108 2 0.5 4 >32 8 9 DNJ-109 1 2 16 16 4 10 DNJ-110 2 8 32 8 ND 11 DNJ-111 4 8 >32 ND 8 12 Linezolid 1 2 0.5 4 4 Sr. No. Representative Compound Bp Se Sp Sa1 Ef1 1 DNJ-201 2 4 1 8 16 2 DNJ-202 1 8 4 8 8 3 DNJ-203 0.5 >16 2 16 8 4 DNJ-204 4 8 8 ND 8 5 DNJ-205 8 8 4 >32 >32 6 DNJ-206 2 2 2 64 64 7 DNJ-207 2 ND 2 ND 4 8 DNJ-208 4 4 2 8 16 9 DNJ-209 >8 2 4 4 >64 10 DNJ-210 16 >16 8 8 32 11 Linezolid 1 2 0.5 4 4 Department of Chemistry, Saurashtra University, Rajkot – 360 005 329
Chapter – 6 Biological evaluation of newly..... Abbreviations Bp : Bacillus pumilus MTCC 1607 Se : Staphylococcus epidermidis MTCC 155 Sp : Staphylococcus pyogenes MTCC 442 Sa1 : Staphylococcus aureus MTCC 96 Ef1 : Enterococcus faecalis MTCC 439 MIC (Minium Inhibitory Concentration in vitro activity µg/ml) values of DNJ- 301 to DNJ-305, DNJ-401 to DNJ-405, DNJ-501 to DNJ-505 and DNJ-601 to DNJ-605 Sr. No. Representative Compound Bp Se Sp Sa1 1 DNJ-301 8 16 >8 64 2 DNJ-302 16 8 16 32 3 DNJ-303 16 32 >64 >32 4 DNJ-304 ND 16 32 16 5 DNJ-305 8 4 2 >8 6 Linezolid 4 4 4 2 Sr. No. Representative Compound Bp Se Sp Sa1 1 DNJ-401 ND ND ND 4 2 DNJ-402 >32 >32 4 32 3 DNJ-403 4 8 16 >8 4 DNJ-404 2 16 >16 4 5 DNJ-405 0.5 ND ND ND 6 Linezolid 4 4 4 2 Sr. No. Representative Compound Bp Se Sp Sa1 1 DNJ-501 4 16 64 4 2 DNJ-502 8 32 16 8 3 DNJ-503 16 64 >8 16 4 DNJ-504 ND 16 ND ND 5 DNJ-505 16 4 >16 8 6 Linezolid 4 4 4 2 Department of Chemistry, Saurashtra University, Rajkot – 360 005 330
Page 1 and 2:
Saurashtra University Re - Accredit
Page 3 and 4:
Statement under O. Ph. D. 7 of Saur
Page 6 and 7:
ACKNOWLEDGEMENT It is a moment of g
Page 8 and 9:
Jignesh Lunagariya, Hitesh Sarvaiya
Page 10 and 11:
CONTENT Content General Remarks 6 A
Page 12 and 13:
Content 3.2 Reaction scheme 149 3.3
Page 14 and 15:
5.14 Conclusion 313 5.15 Spectral r
Page 16 and 17:
MF Molecular Formula MW Molecular W
Page 18 and 19:
GABA Gamma Amino Butyric Acid MES M
Page 20 and 21:
PART - A STUDIES ON 2-METHYL INDOLI
Page 22 and 23:
Part-A Studies on 2-methyl indoline
Page 24 and 25:
Page 26 and 27:
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
CHAPTER - 1 PREPARATION AND YIELD O
Page 44 and 45:
Chapter - 1 Preparation and Yield o
Page 46 and 47:
Page 48 and 49:
Page 50 and 51:
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 68 and 69:
Page 70 and 71:
Page 72 and 73:
Page 74 and 75:
Page 76 and 77:
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Chapter - 2 Microwave assisted simp
Page 84 and 85:
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
Page 102 and 103:
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Part - B Studies on isatin derivati
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
CHAPTER - 3 PREPARATION OF SMALL LI
Page 158 and 159:
Chapter - 3 Preparation of small li
Page 160 and 161:
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
CHAPTER - 4 STUDIES ON DIFFERENT TY
Page 198 and 199:
Chapter - 4 Studies on different ty
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
Page 238 and 239:
Page 240 and 241:
Page 242 and 243:
Page 244 and 245:
Page 246 and 247:
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Chapter - 5 Synthesis and Character
Page 288 and 289: Chapter - 5 Synthesis and Character
Page 336 and 337: Chapter - 6 Biological evaluation o
Page 356 and 357: Summary Synthesis and biological pr
Page 358 and 359: Summary Synthesis and biological pr
Page 360: Conferences / Seminar / Workshop At
show all

Download (4Mb) - Etheses - Saurashtra University

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?