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Chapter – 4 Studies on different types of reactions….. 3°), 1328 (C-N, Ar, 2°), 1164 (>CS, thioamide), 1052 (C-O-C), 990 (C-F), 832 (1,4-di sub); MS m/z = 468 (M + ); Anal. Calcd. for C26H17FN4O2S: C, 66.65; H, 3.66; N, 11.96. Found: C, 66.70; H, 3.70; N, 12.00. Department of Chemistry, Saurashtra University, Rajkot – 360 005 251
Chapter – 4 Studies on different types of reactions….. 4.13 RESULTS AND DISCUSSION Four different schemes had been adopted to build up this chapter. This chapter is mostly related to modification in the previous work done by our group as well as others but the scaffolds reported here are new. Earlier indolinone derivatives were known to be prepared by conventional method using piperidine (base) in refluxing methanol or ethanol. Different 2-indolinone derivatives have been prepared by adopting the conventional method. Moreover, microwave assisted method was also employed to compare both the methods in order to acquire best results. Microwave assisted method found much faster than the conventional one and % yield found to be higher than conventional but the purity was similar in both the methods. It is very well known that C3 position of 4-hydroxycoumarin is highly reactive. 3-acetyl-4-hydroxycoumarin was synthesized by acetylation on 4hydroxycoumarin adopting cited literature method. Chalcones of 3-acetyl-4hydroxycoumarin were prepared using substituted benzaldehydes using piperidine (base) and chloroform which showed good anti viral activity j . In this chapter, continuing previous work chalcones of 3-acetyl-4-hydroxycoumarin using differently substituted pyrazole aldehydes were synthesized using the same experimental protocol. 4-hydroxycoumarin and different pyrazole aldehydes were refluxed in methanol under basic condition in order to prepare coumarin dimers but the 4hydroxycoumarin tautomarize into 2H-chromene-2, 4(3H)-dione and due to the in situ generation of active methylene group it gave arylidine at C3position. Three component Biginelli reaction was used to prepare the coumarin fused pyrimidine derivatives. Mixture of urea / thio urea, pyrazole aldehyde j J. C. Trivedi, J. B. Bariwal, K. D. Upadhyay, Y. T. Naliapara, S. K. Joshi, C. C. Pannecouque, E. De Clercq and A. K. Shah; Tet. Lett., 2007, 48(48), 8472. Department of Chemistry, Saurashtra University, Rajkot – 360 005 252
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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