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Chapter – 3 Preparation of small library….. 3.5.3 Physical data of 1-acetyl-3-[((un)substituted-1, 3-benzothiazol-2- Code yl)imino]-1, 3-dihydro-2H-indol-2-one (DNJ-1501 to DNJ-1505) Substitution R MF MW (g/m) MP (°C) Department of Chemistry, Saurashtra University, Rajkot – 360 005 161 Rf % Yield DNJ-1501 4-H C17H11N3O2S 321 178-180 0.36 57 DNJ-1502 4-OCH3 C18H13N3O3S 351 172-174 0.39 65 DNJ-1503 4-Cl C17H10ClN3O2S 355 216-218 0.37 63 DNJ-1504 4-F C17H10FN3O2S 339 198-200 0.34 58 DNJ-1505 4-NO2 C17H10N4O4S 366 204-206 0.38 60 Rf value was calculated using solvent system = Toluene : Ethyl Acetate (7 : 3) C H 3 N N O N O S R
Chapter – 3 Preparation of small library….. 3.6 SPECTRAL DISCUSSION 3.6.1 MASS SPECTRAL STUDY Mass spectra of the synthesized compounds were recorded on Shimadzu GC-MS QP-2010 model using direct injection probe technique. The molecular ion peak was found in agreement with molecular weight of the respective compound. Characteristic M +2 ion peaks with one-third intensity of molecular ion peak were observed in case of compounds having chlorine atom. Fragmentation pattern can be observed to be particular for these compounds and the characteristic peaks obtained for each compound. Probable fragmentation pattern for DNJ-1301, DNJ-1401 and DNJ-1501 can be discussed as under. N'-1-(morpholin-4-ylmethyl)-2-oxo-1, 2-dihydro-3H-indol-3-ylidene]-2- propylpentanohydrazide (DNJ-1301) 1. The target compound showed characteristic molecular ion peak. 2. C7-N4 bond cleavage gave characteristic peak at 299 m/e. [1] 3. C7-N8 bond cleavage gave two characteristic peaks at 287 m/e and 100 m/e (base peak). [2] 4. After C7-N8 bond cleavage, C27-C28 bond cleavage and subsequently C24-C25 bond cleavage gave characteristic peaks at 272 m/e and 259 m/e respectively. [3] & [4] 5. After C27-C28 and C24-C25 bond cleavages, C26-C27 bond cleavage and subsequently C23-C24 bond cleavage gave two characteristic peaks at 245 m/e and 216 m/e respectively. [5] & [6] 6. After C26-C27 and C23-C24 bond cleavages, C20-C22 bond cleavage and subsequently C20-C21 bond cleavage gave two characteristic peaks at 188 m/e and 175 m/e respectively. [7] & [8] 7. After C20-C22 and C20-C21 bond cleavages, N19-C20 bond cleavage gave characteristic peak at 160 m/e. [9] Department of Chemistry, Saurashtra University, Rajkot – 360 005 162
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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