Download (4Mb) - Etheses - Saurashtra University

Chapter – 6 Biological evaluation of newly.....
compound having piperidine subunit (i.e. DNJ-1402) was found to be
moderate active against stomach cancer cell line while it was found to be less
active against rests of the two cancer cell lines. Moreover the compound
having N-benzyl piperazine subunit (i.e. DNJ-1405) was found to be moderate
active against lung cancer cell line while it was found to be less active against
rests of the two cancer cell lines. The compound having N-methyl piperazine
subunit (i.e. DNJ-1403) was found to possess less cytotoxic activity against all
the three cancer cell lines while the compound having N-ethyl piperazine
subunit (i.e. DNJ-1404) was found to possess moderate cytotoxic activity
against stomach and breast cancer cell lines and less cytotoxic activity
against lung cancer cell line.
In case of DNJ-1501 to DNJ-1505, DNJ-1501 was found to possess
less cytotoxic activity against all the three cancer cell lines. DNJ-1502 was
found to be good active against stomach cancer cell line with the ED50 value
39 µg/ml while it was found to be less active against rests of the two cancer
cell lines with the ED50 value more than 100 µg/ml. DNJ-1503 and DNJ-1504
were found to possess less cytotoxic activity against stomach (ED50 : >100
and 89 µg/ml respectively) and lung cancer (ED50 : >100 µg/ml) cell lines
while they were found to possess moderate cytotoxic activity (ED50 : 81 and
61 µg/ml respectively) against breast cancer cell line. DNJ-1505 was found to
be good active (ED50 : 30 µg/ml) against stomach cancer cell line while it was
found to be moderate active against breast (ED50 : 50 µg/ml) and lung (ED50 :
84 µg/ml) cancer cell lines. Thus from above results it could be summarized
that the compound having no substitution in benzothiazole subunit (i.e. DNJ-
1501) found to be less active against all the three cancer cell lines.
Furthermore the compound having methoxy group at 6 th position in
benzothiazole subunit (i.e. DNJ-1502) was found to be good active against
stomach cancer cell line while it was found to be less active against rests of
the two cancer cell lines. Moreover the compounds having halogen group (i.e.
Cl and F) at 6 th position in benzothiazole subunit (i.e. DNJ-1503 and DNJ-
1504) were found to possess less cytotoxic activity against stomach and lung
cancer cell lines while they were found to possess moderate cytotoxic activity
against breast cancer cell line. The compound having nitro group at 6 th
Department of Chemistry, Saurashtra University, Rajkot – 360 005 337