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Chapter – 5 Synthesis and Characterization….. DNJ 1012 DNJ 1013 DNJ 1014 DNJ 1015 1-ethyl piperazinyl 1-ethyl piperazinyl 3-methoxy phenyl amino C23H27N3O3 393 166 0.47 56 3trifluoromethyl phenyl amino C23H24F3N3O2 431 182 0.43 66 1-ethyl piperazinyl Octyl amino C24H37N3O2 399 200 0.48 40 1-ethyl piperazinyl 2-furyl methyl amino C21H25N3O3 367 196 0.41 50 Rf value was calculated using solvent system = Toluene : Ethyl Acetate (70% : 30%) Department of Chemistry, Saurashtra University, Rajkot – 360 005 297
Chapter – 5 Synthesis and Characterization….. 5.10 SPECTRAL DISCUSSION 5.10.1 MASS SPECTRAL STUDY Mass spectra of the synthesized compounds were recorded on Shimadzu GC-MS QP-2010 model using direct injection probe technique. The molecular ion peak was found in agreement with molecular weight of the respective compound. Characteristic M +2 ion peaks with one-third intensity of molecular ion peak were observed in case of compounds having chlorine atom. Fragmentation pattern can be observed to be particular for these compounds and the characteristic peaks obtained for each compound. Probable fragmentation pattern for DNJ-1013 can be discussed as under. 4-[(3-chlorophenyl) amino]-3-[(4-ethylpiperazin-1-yl) methyl]-2H- chromen-2-one (DNJ-1013) 1. The target compound showed characteristic molecular ion peak. 2. C26-C27 bond cleavage gave characteristic peak at 416 m/e. [1] 3. N16-C26 bond cleavage gave characteristic peak at 403 m/e. [2] 4. Cleavage of the bonds C15-N16 and C17-N15 gave characteristic peak at 389 m/e. [3] 5. Cleavage of the bond C17-C18 gave characteristic peak at 374 m/e. [4] 6. C14-C15 bond cleavage gave characteristic peak at 359 m/e. [5] 7. Cleavage of the bond N13-C18 gave characteristic peak at 346 m/e. [6] 8. N13-C14 bond cleavage gave characteristic peak at 331 m/e. [7] 9. Cleavage of the bond C12-N13 gave two characteristic peaks. One at 316 m/e and second at 113 m/e. [8] 10. C24-C28 bond cleavage gave characteristic peak at 248 m/e. [9] 11. Cleavage of the bond C3-C12 gave characteristic peak at 235 m/e. [10] 12. N19-C20 bond cleavage gave two characteristic peaks. One at 287 m/e and second at 145 m/e. [11] 13. Cleavage of the bond C4-N19 gave characteristic peak at 272 m/e. [12] Department of Chemistry, Saurashtra University, Rajkot – 360 005 298
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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