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Chapter – 3 Preparation of small library….. 3.3.3 SCHEME - 3 O N CH 3 O : N H O + H O + + O H2N S N N R N H OH + LG = Leaving Group O C H 3 LG + H : : N N S O Department of Chemistry, Saurashtra University, Rajkot – 360 005 153 S N N R R - H + NH O OH NH : + H -H2 O + N H NH + O S N S N R R
Chapter – 3 Preparation of small library….. 3.4 EXPERIMENTAL 3.4.1 PREPARATION OF METHYL 2-PROPYLPENTANOATE 0.01 mole of 2-propyl pentanoic acid was charged into 250 ml round bottom flask. 15 ml of methanol was added into above flask. 3-4 drops of Con. Sulphuric acid was added as a catalyst. The reaction mixture was refluxed for 12-14 hours on water bath. The progress and the completion of the reaction were checked by silica gel-G F254 thin layer chromatography using hexane : ethyl acetate (4 : 6) as a mobile phase. After the reaction to be completed excess of methanol was removed under reduced pressure. The separated product was extracted using ethyl acetate (30 ml X 3), the combined organic layer was washed using 5% sodium bicarbonate solution (20 ml X 2) followed by water (20 ml X 2). The organic layer was dried on anhydrous sodium sulphate and the solvent was removed under reduced pressure to acquire the product in a viscous liquid form. Yield - 90 %, B. P. - 190-195°C. 3.4.2 PREPARATION OF 2-PROPYLPENTANOHYDRAZIDE 0.01 mole of methyl 2-propylpentanoate was charged into 250 ml round bottom flask. 15 ml of hydrazine hydrate was added into above flask. The reaction mixture was refluxed on water bath for 12-14 hours. The progress and the completion of the reaction were checked by silica gel-G F254 thin layer chromatography using hexane : ethyl acetate (4 : 6) as a mobile phase. After the reaction to be completed, the mixture was cooled to room temperature to give 2-propylpentanohydrazide as a white coloured shining fluffy product. Yield - 60 %, M. P. - 120-122°C. 3.4.3 PREPARATION OF ISATIN-N-MANNICH BASES It was prepared according to the method described by Varma and Nobles. a To slurry consisting of 0.04 mole of isatin, 5 ml 50% ethanol and 5 ml formaldehyde solution (37-41%) was added 0.04 mole of the desired a R. S. Varma and W. L. Nobles; J. Het. Chem., 1966, 3(4), 462. Department of Chemistry, Saurashtra University, Rajkot – 360 005 154
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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