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Chapter – 3 Preparation of small library….. 8. After N19-C20 bond cleavage, N18-N19 bond cleavage gave characteristic peak at 147 m/e. [10] 9. After N18-N19 bond cleavage, C10-N18 bond cleavage gave 10. characteristic peak at 132 m/e. [11] After C10-N18 bond cleavage, C9-O17 bond cleavage gave characteristic peak at 119 m/e. [12] 3.6.1.1 FRAGMENTATION PATTERN FOR DNJ-1301 O 6 O 1 5 2 NH N 4 3 N N CH 3 O NH O CH 3 CH 3 28 27 26 27 26 O 26 CH3 27 21 O 22 21 O 20 22 21 20 22 20 23 23 NH 23 N 19 NH 18 24 N 19 NH 18 24 N 19 16 18 24 10 16 15 11 CH3 [2] 10 16 25 15 11 CH3 [3] 10 9 25 15 11 CH [4] 3 O 9 25 14 12 17 O 9 14 12 17 O 13 N 14 12 17 8 13 N H 13 N 7 8 H 8 [1] +. 91 m/e 386 m/e 299 m/e CH 3 3-(1, 3-benzothiazol-2-ylimino)-1-(morpholin-4-ylmethyl)-1, 3-dihydro-2H- indol-2-one (DNJ-1401) 15 14 +. [10] 16 13 15 14 10 11 9 12 N H 8 160 m/e N 18 16 13 O NH 2 19 O 17 N NH 18 CH 3 10 11 9 12 N H 8 147 m/e +. 100 m/e +. [9] +. O 17 15 14 287 m/e 16 13 CH 3 28 16 [11] [12] 15 14 N 18 10 11 9 12 N H 8 175 m/e +. 13 10 11 9 12 N H 8 132 m/e CH 3 20 NH 19 O 17 1. The target compound showed characteristic molecular ion peak. 2. C21-N13 bond cleavage gave two characteristic peaks at 279 m/e and 104 m/e. [1] 3. O25-C24 and O25-C26 bond cleavages gave characteristic peak at 365 m/e. [2] Department of Chemistry, Saurashtra University, Rajkot – 360 005 163 +. O 17 272 m/e N H 15 14 15 14 16 13 N 18 10 11 9 12 N H 8 16 13 O 21 22 20 23 N 18 NH 19 10 11 9 12 N H 8 O 17 NH 19 26 H3C 24 O 17 CH 3 27 CH3 O 26 21 22 20 23 H3C 24 O O 21 +. 21 +. 22 20 20 +. CH3 NH 23 NH N 19 N 19 18 18 16 16 10 [8] 10 [7] 15 11 15 11 9 O 9 O 14 12 17 14 12 17 13 N 13 N H H 8 8 188 m/e 117 m/e +. +. [5] [6] 216 m/e 259 m/e 245 m/e +. +.
Chapter – 3 Preparation of small library….. 4. After O25-C24 and O25-C26 bond cleavages, C23-C24 bond cleavage gave characteristic peak at 353 m/e. [3] 5. After C23-C24 bond cleavage, C26-C27 bond cleavage gave characteristic peak at 333 m/e. [4] 6. After C26-C27 bond cleavage, N22-C23 bond cleavage gave characteristic peak at 318 m/e. [5] 7. After N22-C23 bond cleavage, N22-C27 bond cleavage gave characteristic peak at 307 m/e. [6] 8. After N22-C27 bond cleavage, C21-N22 bond cleavage gave characteristic peak at 290 m/e (base peak). [7] 9. After C21-N22 bond cleavage, N13-C21 bond cleavage gave 10. characteristic peak at 279 m/e. [8] C2-N10 bond cleavage gave two characteristic peaks at 249 m/e and 132 m/e. [9] 11. After C2-N10 bond cleavage, N10-C11 bond cleavage gave characteristic peak at 234 m/e. [10] 12. After N10-C11 bond cleavage, O25-C24 and O25-C26 bond cleavages gave characteristic peak at 213 m/e. [11] 13. After O25-C24 and O25-C26 bond cleavages, C23-C24 bond cleavage gave characteristic peak at 205 m/e. [12] 14. After C23-C24 bond cleavage, C26-C27 bond cleavage gave characteristic peak at 186 m/e. [13] 15. After C26-C27 bond cleavage, N13-C21 bond cleavage gave characteristic peak at 132 m/e. [14] 16. After N13-C21 bond cleavage, C12-O20 bond cleavage gave characteristic peak at 121 m/e. [15] Department of Chemistry, Saurashtra University, Rajkot – 360 005 164
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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