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Chapter – 6 Biological evaluation of newly.....
lung cancer cell line. DNJ-1302 was found to be less active against all the
three cancer cell lines while DNJ-1303 was found to be moderate active
against breast cancer cell line and less active against rests of the two cancer
cell lines. Thus from above results it could be summarized that the compound
having N-ethyl piperazine subunit (i.e. DNJ-1304) found to be most potent
molecule against all the three cancer cell lines while the compound having
piperidine subunit (i.e. DNJ-1302) did not show good cytotoxic activity.
Furthermore the compound having N-benzyl piperazine subunit (i.e. DNJ-
1305) found to be good active against stomach cancer cell line while it found
to be moderate active against breast cancer cell line but its activity against
lung cancer cell line was less. The compound having morpholine subunit (i.e.
DNJ-1301) found to be good active against stomach cancer cell line while it
found to be moderate active against breast cancer cell line but its activity
against lung cancer cell line was less. Moreover, the compound having Nmethyl
piperazine subunit (i.e. DNJ-1303) found to be less active against
stomach and lung cancer cell line while it found to be moderate active against
breast cancer cell line.
In case of DNJ-1401 to DNJ-1405, DNJ-1401 was found to be good
active against stomach cancer cell line and breast cancer cell line with the
ED50 values 38 and 35 µg/ml respectively but it was found less active against
lung cancer cell line with ED50 value more than 100 µg/ml. DNJ-1402 was
found to be moderate active (ED50 : 49 µg/ml) against stomach cancer cell line
while it was found to be less active (ED50 : >100 µg/ml) against rests of the
two cancer cell lines. DNJ-1403 was found to be less active against all the
three cancer cell lines. DNJ-1404 was found to be moderate active (ED50 : 73
µg/ml) against stomach (ED50 : 61 µg/ml) and breast cancer cell line while it
was found to be less active (ED50 : >100 µg/ml) against lung cancer cell line.
DNJ-1405 was found to be less active (ED50 : >100 µg/ml) against stomach
and breast cancer cell lines while it was found to be moderate active (ED50 :
74 µg/ml) against lung cancer cell line. Thus from above results it could be
summarized that the compound having morpholine subunit (i.e. DNJ-1401)
possess good cytotoxic activity against stomach and breast cancer cell lines
while it showed less activity against lung cancer cell line. Furthermore the
Department of Chemistry, Saurashtra University, Rajkot – 360 005 336