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Chapter – 6 Biological evaluation of newly.....
samples and positive and negative controls, were incubated at 37C for 16-18
hours. The wells were visually inspected for growth and were also reat at 630
nm by Automated Micropalte Reader [(EL800) Trinity Biotech] and the MICs
were recorded as the lowest concentration of drug which inhibits the growth of
bacteria.
MIC (Minium Inhibitory Concentration in vitro activity µg/ml) values of DNJ-
101 to DNJ-111 and DNJ-201 to DNJ-210
ND = Not Done
Sr.
No.
Representative
Compound
Bp Se Sp Sa1 Ef1
1 DNJ-101 0.5 1 4 8 2
2 DNJ-102 2 0.5 2 16 4
3 DNJ-103 4 4 1 32 2
4 DNJ-104 2 0.5 >16 >16 8
5 DNJ-105 2 2 8 4 >16
6 DNJ-106 4 1 2 ND 32
7 DNJ-107 2 4 1 >8 16
8 DNJ-108 2 0.5 4 >32 8
9 DNJ-109 1 2 16 16 4
10 DNJ-110 2 8 32 8 ND
11 DNJ-111 4 8 >32 ND 8
12 Linezolid 1 2 0.5 4 4
Sr.
No.
Representative
Compound
Bp Se Sp Sa1 Ef1
1 DNJ-201 2 4 1 8 16
2 DNJ-202 1 8 4 8 8
3 DNJ-203 0.5 >16 2 16 8
4 DNJ-204 4 8 8 ND 8
5 DNJ-205 8 8 4 >32 >32
6 DNJ-206 2 2 2 64 64
7 DNJ-207 2 ND 2 ND 4
8 DNJ-208 4 4 2 8 16
9 DNJ-209 >8 2 4 4 >64
10 DNJ-210 16 >16 8 8 32
11 Linezolid 1 2 0.5 4 4
Department of Chemistry, Saurashtra University, Rajkot – 360 005 329