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PART – A STUDIES ON 2-METHYL INDOLINE DERIVATIVES A.1 Introduction to indole system 12 A.1.1 Physical properties of indole 12 A.2 Introduction to indoline system 13 A.2.1 Reduction of indole 13 A.2.2 Preparation of 2-methyl indoline 17 A.2.3 N-alkylation on 2-methyl indoline 19 A.2.4 Mannich reaction on 2-methyl indoline 26 A.3 References 27
Part-A Studies on 2-methyl indoline derivatives….. A.1 INTRODUCTION TO INDOLE SYSTEM Indole (2, 3-benzopyrrole, ketole, 1-benzazole; C8H7N) is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a sixmembered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The participation of the nitrogen lone electron pair in the aromatic ring means that indole is not a base, and it does not behave like a simple amine. Indole is a solid at room temperature. Indole can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many flower scents (such as orange blossoms) and perfumes. It also occurs in coal tar. Many researchers have described synthesis of indole and its derivatives along with its applications in literature. 1-47 A.1.1 PHYSICAL PROPERTIES OF INDOLE 5 6 4 7 Indole is a white coloured solid, melting at 52-54°C and boiling at 253- 254 °C. 0.19 gm of indole is soluble in 100 ml of hot water. Indole is soluble in alchohol, ethylacetate etc. Indole is having planar molecular shape, 1.22 g/cm 3 density and 2.11 D dipole moment in benzene. All indole derivatives show certain family resemblances to indole 4 , but striking changes can be brought about by substitution of groups in the pyrrole ring. Thus, the fecal-like Department of Chemistry, <strong>Saurashtra</strong> <strong>University</strong>, Rajkot – 360 005 12 3 N H 1 Fig. A.1 2
Page 1 and 2: Saurashtra University Re - Accredit
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Page 6 and 7: ACKNOWLEDGEMENT It is a moment of g
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Page 10 and 11: CONTENT Content General Remarks 6 A
Page 12 and 13: Content 3.2 Reaction scheme 149 3.3
Page 14 and 15: 5.14 Conclusion 313 5.15 Spectral r
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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