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Chapter – 4 Studies on different types of reactions…..
and 4-hydroxycoumarin was refluxed into methanol under acidic condition to
give rise to the expected product.
4.14 CONCLUSION
2-Indolinone derivatives have recently been established as an anti
cancer compounds and more specifically as tyrosine kinase inhibitors
(SU5416, SU5614, SU6668, SU6597, SU6663 and SU6561) that block kit
activation and growth of small cell in lung cancer. Moreover Virsodia et. al. a
reported the anticancer evaluation results of the arylidine products of 1-(2, 6dichlorophenyl)-2-indolinone.
Biological importance of such scaffolds inspired
us to prepare new indolinone derivatives and to carry out their anticancer
evaluation.
4-hydroxycoumarin is a versatile scaffold and is being consistently
used as a building block in organic chemistry as well as in heterocyclic
chemistry for the synthesis of different heterocycles. The synthetic versatility
of 4-hydroxycoumarin has led to the extensive use of this compound in
organic synthesis. 4-hydroxy coumarin shows diversified chemical reactivity
and biological profile. Thus it was of interest to study the biological activities of
newly synthesized coumarin derivatives.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 253