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Part – B Studies on isatin derivatives…..
Bekircan and Bektas 260 reported preparation of Schiff base of
substituted isatins and substituted 4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5ones
which afterwards underwent Mannich reaction using piperidine and
formaldehyde to give title compounds. (Fig. B.1.30) (R = 2-fluoro aniline and
4-fluoro aniline, X = H, Cl)
Fig. B.1.30
B.7 BIOLOGICAL ACTIVITIES ASSOCIATED WITH ISATINS
Several isatin derivatives are showing excellent pharmacological
profiles. Following biological activities are reported for isatins developed by
various research groups and explored.
1 CNS depressant activities 261-263
2 Anticonvulsant activity 264-295
3 Anxiogenic and other CNS activities 296-302
4 Antimicrobial activity 303-329
5 Anticancer activity 330-340
341, 342
6 Antiplasmodial activity
7 Antitubercular activity 343-345
346, 347
8 Inhibitor of glucose, aminoacid uptake
9 Isatin derivatives as serine protease inhibitors 348
10 Isatin derivatives as SARS (Severe Acute Respiratory Syndrome)
coronavirus 3CL protease inhibitors 349
11 Isatin derivatives as oxytosin receptor antagonists 350
Department of Chemistry, Saurashtra University, Rajkot-360 005 131