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Chapter – 2 Microwave assisted simple and fast….. 2.5.4 Physical data of 1-(2-substituted-4-yl-2-oxoethyl)-1H-indole-2, 3- dione (DNJ-601 to DNJ-605) Code Substitution R1 & R2 Department of Chemistry, Saurashtra University, Rajkot – 360 005 87 MF MW (g/m) MP (°C) DNJ-601 Piperidinyl C15H16N2O3 272 178-180 0.43 DNJ-602 Morpholinyl C14H14N2O4 274 168-170 0.42 DNJ-603 1-methyl piperazinyl C15H17N3O3 287 162-164 0.44 DNJ-604 1-ethyl piperazinyl C16H19N3O3 301 184-186 0.48 DNJ-605 1-benzyl piperazinyl C21H21N3O3 363 174-176 0.43 Rf value was calculated using solvent system = Toluene : Ethyl Acetate (7 : 3) O R 1 N N O R 2 O Rf
Chapter – 2 Microwave assisted simple and fast….. 2.6 SPECTRAL DISCUSSION 2.6.1 MASS SPECTRAL STUDY Mass spectra of the synthesized compounds were recorded on Shimadzu GC-MS QP-2010 model using direct injection probe technique. The molecular ion peak was found in agreement with molecular weight of the respective compound. Characteristic M +2 ion peaks with one-third intensity of molecular ion peak were observed in case of compounds having chlorine atom. Fragmentation pattern can be observed to be particular for these compounds and the characteristic peaks obtained for each compound. Probable fragmentation pattern for DNJ-302, DNJ-402, DNJ-502 and DNJ- 602 can be discussed as under. 2-methyl-1-(3-morpholin-4-ylpropyl) indoline (DNJ-302) 1. The target compound showed characteristic molecular ion peak. 2. O1-C2 and O1-C6 bond cleavages gave characteristic peak at 245 m/e. [1] 3. After O1-C2 and O1-C6 bond cleavages, C2-C3 bond cleavage gave characteristic peak at 229 m/e. [2] 4. After C2-C3 bond cleavage, C5-C6 bond cleavage gave characteristic peak at 223 m/e. [3] 5. After C5-C6 bond cleavage, C3-N4 bond cleavage and subsequently N4- C5 bond cleavage gave two characteristic peaks at 208 m/e and 186 m/e respectively. [4] & [5] 6. After C3-N4 and N4-C5 bond cleavages, C7-N4 bond cleavage gave characteristic peak at 172 m/e. [6] 7. After C7-N4 bond cleavage, C7-C8 and C8-C9 bond cleavages gave two characteristic peaks at 158 m/e and 146 m/e (BASE PEAK). [7] & [8] 8. After C7-C8 and C8-C9 bond cleavages, C9-N10 and C11-C19 bond cleavages gave two characteristic peaks at 130 m/e and 118 m/e. [9] & [10] Department of Chemistry, Saurashtra University, Rajkot – 360 005 88
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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