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Chapter – 1 Preparation and Yield optimization.....
0.015 mole of formaldehyde (37-41% w/w solution) and 10 ml diethylether
were added into above flask and the mixture was magnetically stirred for
some time at room temperature under acidic condition. 0.01 mole of an
appropriately substituted primary amine was added drop wise into above
reaction mixture. Stirring was continued for further half an hour at room
temperature. The progress and the completion of the reaction were checked
by silica gel-G F254 thin layer chromatography using hexane : ethyl acetate (9 :
1) as a mobile phase. After the reaction to be completed, the reaction mixture
was extracted using ethyl acetate (30 ml X 3). The combined organic layer
was washed using water (20 ml X 2). The organic layer was dried over
anhydrous sodium sulphate and the solvent was removed under reduced
pressure to acquire the product. (Physical data of the synthesized end
products are summarized in the table 1.5.2)
Department of Chemistry, Saurashtra University, Rajkot-360 005 43