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Chapter – 4 Studies on different types of reactions…..
Novel oxime-derivatives of indirubin, a metabolite of isatin oxidation
and an active ingredient of a traditional Chinese medicine containing a bisoxindole
skeleton have been recently developed, based on structure-activity
relationship studies, as potent cancer cell growth inhibitors for different cell
lines. Recent investigations indicated that these oxindoles display high
inhibition of some cyclin-dependent kinases (CDK2). 128 (Fig. 4.7)
Fig. 4.7
Moreover recently Virsodia et. al. 129 reported in vitro anticancer
evaluation of 1-(2, 6-dichlorophenyl)-3-methylene-1, 3-dihydro indole-2-one
derivatives against SW 620 colon cancer cell line. (Fig. 4.8)
Fig. 4.8
Where R = Differently substituted benzaldehydes
Department of Chemistry, Saurashtra University, Rajkot – 360 005 198