Download (4Mb) - Etheses - Saurashtra University

Chapter – 1 Preparation and Yield optimization.....
1.6.1.1 FRAGMENTATION PATTERN FOR DNJ-102
N
146 m/e
CH 3
N – Methyl – N - [(2 – methyl - 2, 3 – dihydro - 1H – indol – 1 - yl) methyl]
aniline (DNJ-206)
N
H 2
N
160 m/e
CH 3
130 m/e
+ .
NH
CH 3
CH 3
[3]
1. The target compound showed characteristic molecular ion peak.
2. Cleavage of the bonds between C15-C16 and C18-C19 gave
characteristic peak at 216 m/e. [1]
3. Cleavage of the bonds between C14-C15 and C14-C19 gave
characteristic peak 190 m/e. [2]
+ .
[2]
CH 3
N
O
+ .
100 m/e
+ .
15
[4]
16
C
H 3
14
Department of Chemistry, Saurashtra University, Rajkot-360 005 47
[1]
11
10
13
12
N
N
CH 3
190 m/e
9
N 8
5
6
232 m/e
CH 3
17
7
N 4
O 1
CH 3
3
2
+ .
[4]
15
16
14
11
10
13
12
130 m/e
[5]
118 m/e
9
NH
8
NH
+ .
CH 3
17
+ .