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Chapter – 5 Synthesis and Characterization…..
5.6 REACTION SCHEMES
5.6.1 PREPARATION OF 4-HYDROXY COUMARIN
Reagents / Reaction Condition (a): Anhydrous ZnCl2, POCl3 / 70°C, 12 hours.
5.6.2 PREPARATION OF 4-(SUBSTITUTED ANILINO) COUMARIN
Reagents / Reaction Condition (b): Substituted primary amines / MW, 320
Watt.
5.6.3 PREPARATION OF ARYL AMINO COUMARIN C-MANNICH BASES
R 5
R 4
OH
+
HO
O O
OH
O O
NH
R 3
O
R
OH
c
b
Reagents / Reaction Condition (c): Formaldehyde (37-41 % solution),
Secondary amine, DMF, Con. HCl / Warm→Room Temperature
Department of Chemistry, Saurashtra University, Rajkot – 360 005 292
O
NH 2
R 5
a
R
R 4
O O
OH
O O
NH
O O
NH N
R 1
R 3
R 2