Download (4Mb) - Etheses - Saurashtra University

Chapter – 3 Preparation of small library…..
3.4.8 GENERAL PROCEDURE FOR THE PREPARATION OF DNJ-1501
TO DNJ-1505
It was prepared according to the method described by Jacobs et. al. g
0.01 mole of an appropriate Schiff base of isatin was charged into 50 ml round
bottom flask. 3.5 ml acetic anhydride was added into it and the reaction
mixture was refluxed for 4 hour with constant stirring. The progress and the
completion of the reaction were checked by silica gel-G F254 thin layer
chromatography using toluene : ethyl acetate (7 : 3) as a mobile phase. After
the reaction to be completed, the flask was cooled to give desired product,
which was washed with diethyl ether and dried. Recrystallization was carried
out from methanol. (Physical data of the synthesized end products are
summarized in the table 3.5.3)
g T. L. Jacobs, S. Winstein, G. B. Linden, J. H. Robson, E. F. Levy and D. Seymour; Org.
Synth., 1948, 28, 70.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 158