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Chapter – 1 Preparation and Yield optimization..... 1.5.2 Physical data of N-substituted 2-methyl indoline N-Mannich bases (DNJ-201 to DNJ-210) Code Substitution R1 Department of Chemistry, Saurashtra University, Rajkot-360 005 45 MF MW (g/m) Rf % Yield DNJ-201 Aniline C16H18N2 238 0.56 61 DNJ-202 3-chloro aniline C16H17ClN2 272 0.58 55 DNJ-203 3-trifluoromethyl aniline C17H17F3N2 306 0.58 77 DNJ-204 3-methyl aniline C17H20N2 252 0.58 75 DNJ-205 3-methoxy aniline C17H20N2O 268 0.59 50 DNJ-206 N-methyl aniline C17H20N2 252 0.57 65 DNJ-207 N, N-diphenyl amine C22H22N2 314 0.64 67 DNJ-208 3-amino pyridine C15H17N3 239 0.55 79 DNJ-209 4-amino pyridine C15H17N3 239 0.54 72 DNJ-210 Furfuryl amine C15H18N2O 242 0.53 56 Rf value was calculated using solvent system = Hexane : Ethyl Acetate (9 : 1) HN N R 1 CH 3
Chapter – 1 Preparation and Yield optimization..... 1.6 SPECTRAL DISCUSSION 1.6.1 MASS SPECTRAL STUDY Mass spectra of the synthesized compounds were recorded on Shimadzu GC-MS QP-2010 model using direct injection probe technique. The molecular ion peak was found in agreement with molecular weight of the respective compound. Characteristic M +2 ion peaks with one-third intensity of molecular ion peak were observed in case of compounds having chlorine atom. Fragmentation pattern can be observed to be particular for these compounds and the characteristic peaks obtained for each compound. Probable fragmentation pattern for DNJ-102 and DNJ-206 can be discussed as under. 2-methyl-1-(morpholin-4-ylmethyl) indoline (DNJ-102) 1. The target compound showed characteristic molecular ion peak. 2. C2-C3 and C5-C6 bond cleavage gave characteristic peak at 190 m/e. [1] 3. C3-N4 and C5-N4 bond cleavage gave characteristic peak at 160 m/e. [2] 4. N4-C7 bond cleavage gave characteristic peak, which is the BASE PEAK at 146 m/e. [3] 5. C7-N8 bond cleavage gave two characteristic peaks. One peak at 130 m/e and second peak at 100 m/e , which is the second intense peak in the spectrum. [4] 6. After cleaved from bond C7-N8, C9-C17 bond cleavage gave characteristic peak at 118 m/e. [5] Department of Chemistry, Saurashtra University, Rajkot-360 005 46
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Saurashtra University Re - Accredit
Page 3 and 4: Statement under O. Ph. D. 7 of Saur
Page 6 and 7: ACKNOWLEDGEMENT It is a moment of g
Page 8 and 9: Jignesh Lunagariya, Hitesh Sarvaiya
Page 10 and 11: CONTENT Content General Remarks 6 A
Page 12 and 13: Content 3.2 Reaction scheme 149 3.3
Page 14 and 15: 5.14 Conclusion 313 5.15 Spectral r
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Page 22 and 23: Part-A Studies on 2-methyl indoline
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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