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Chapter – 4 Studies on different types of reactions….. 4.9.7 GENERAL PROCEDURE FOR THE PREPARATION OF DNJ-1601 TO DNJ-1605 AND DNJ-1701 TO DNJ-1705 0.015 mole of urea / thiourea was dissolved into 20 ml of methanol. 0.01 mole of an appropriately substituted pyrazole-4-carboxaldehyde was added to above reaction mixture and additional 20 ml of methanol was added along with few drops of concentrated hydrochloric acid. This reaction mixture was transferred to 250 ml round bottom flask containing 0.01 mole of 4hydroxycoumarin into 10 ml of methanol. The content of the flask was heated on water bath for 5-6 hours. The progress and the completion of the reaction were checked by silica gel-G F254 thin layer chromatography using toluene : ethyl acetate (7 : 3) as a mobile phase. After the reaction to be completed, the reaction mixture was cooled to room temperature and the product was separated by filtration. The product was washed with methanol and dried to give desired product in moderate yield which was recrystallized by DMF. (Physical data of the synthesized end products are summarized in the table 4.10.4 & 4.10.5) Department of Chemistry, Saurashtra University, Rajkot – 360 005 229
Chapter – 4 Studies on different types of reactions….. 4.10 PHYSICAL DATA TABLES 4.10.1 Physical data of 1-(2, 6-dichlorophenyl)-3-{[3-(substituted phenyl)- 1-phenyl-1H-pyrazol-4-yl] methylene}-1, 3-dihydro-2H-indol-2-one Code (DNJ-701 to DNJ-705) Substitution R MF MW (g/m) MP (°C) DNJ-701 4-NO2 C30H18Cl2N4O3 553 250-252 0.62 DNJ-702 3-NO2 C30H18Cl2N4O3 553 268-270 0.61 DNJ-703 H C30H19Cl2N3O 508 224-226 0.55 DNJ-704 4-F C30H18Cl2FN3O 526 240-242 0.57 DNJ-705 4-Cl C30H18Cl3N3O 542 256-258 0.60 Rf value was calculated using solvent system = Hexane : Ethyl Acetate (6 : 4) Cl R N O Department of Chemistry, Saurashtra University, Rajkot – 360 005 230 Cl N N Rf
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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