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Chapter – 4 Studies on different types of reactions…..
4.11.1.1 FRAGMENTATION PATTERN FOR DNJ-705
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Cl
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+.
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Cl
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N 1
2
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26
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3-{(2Z)-3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl] prop-2-enoyl}-4-
hydroxy-2H-chromen-2-one (DNJ-804)
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O 16
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Cl
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N 20
N 21
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Cl
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1. The target compound showed characteristic molecular ion peak.
2. Loss of hydroxyl group, substituted at C4 position, gave characteristic
peak at 449 m/e. [1]
3. C3-C12 bond cleavage gave two characteristic peaks at 307 m/e and
162 m/e respectively. [2]
4. C12-C15 bond cleavage gave two characteristic peaks at 279 m/e and
189 m/e. [3]
5. C15-C16 bond cleavage gave characteristic peak at 265 m/e. [4]
Department of Chemistry, Saurashtra University, Rajkot – 360 005 236
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Cl
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Cl
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N
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26 25
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N
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N
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2 O
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N
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[3]
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+. Cl
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28 29
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[4]
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Cl
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N
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N
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2 O 33
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N
1 Cl
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10 542 m/e
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[6]
+. 29
478 m/e
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[5]
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26 25
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506 m/e
+.
[2]
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N
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N 20
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N
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NH
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35
31
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3
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8 4
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2 O 33
2 O 7 5
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6 N
6 N 464 m/e 1 442 m/e
1 Cl
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Cl
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[1]
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+.
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Cl
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N 20
N 21
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524 m/e
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35
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Cl
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N 1
2
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Cl
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+.
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O 16
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29
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Cl
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30
19
290 m/e
+.
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N 20
N 21
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32
253 m/e
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